LitCoin-sentences  

PubMed:26270232 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma.
T2 114-125 Sentence denotes BACKGROUND:
T3 126-199 Sentence denotes Most hepatocellular carcinomas (HCCs) are diagnosed at an advanced stage.
T4 200-320 Sentence denotes The prognostic value of serum tumour markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) is limited.
T5 321-483 Sentence denotes The aim of our study is to evaluate the diagnostic value of serum growth factors, apoptotic and inflammatory mediators of cirrhotic patients with and without HCC.
T6 484-492 Sentence denotes METHODS:
T7 493-659 Sentence denotes Serum samples were collected from cirrhotic potential liver transplant patients (LTx) with (n=61) and without HCC (n=78) as well as from healthy controls (HCs; n=39).
T8 660-927 Sentence denotes Serum concentrations of CRP, neopterin and IL-6 as markers of inflammation and thrombopoietin (TPO), GCSF, FGF basic and VEGF, HMGB1, CK-18 (M65) and CK18 fragment (M30) and a panel of proinflammatory chemokines (CCL2, CCL3, CCL4, CCL5, CXCL5 and IL-8) were measured.
T9 928-1058 Sentence denotes Chi square, Fisher exact, Mann-Whitney U-tests, ROC curve analysis and forward stepwise logistic regression analyses were applied.
T10 1059-1067 Sentence denotes RESULTS:
T11 1068-1230 Sentence denotes Patients with HCC had higher serum TPO and chemokines (P<0.001 for TPO, CCL4, CCL5 and CXCL5) and lower CCL2 (P=0.008) levels than cirrhotic patients without HCC.
T12 1231-1403 Sentence denotes Multivariate forward stepwise regression analysis for significant parameters showed that among the studied parameters CCL4 and CCL5 (P=0.001) are diagnostic markers of HCC.
T13 1404-1522 Sentence denotes Serum levels of TPO and chemokines were lower, whereas M30 was significantly higher in cirrhotic patients than in HCs.
T14 1523-1535 Sentence denotes CONCLUSIONS:
T15 1536-1667 Sentence denotes High serum levels of inflammatory chemokines such as CCL4 and CCL5 in the serum of cirrhotic patients indicate the presence of HCC.