| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-120 |
Sentence |
denotes |
The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice. |
| T2 |
121-227 |
Sentence |
denotes |
Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. |
| T3 |
228-461 |
Sentence |
denotes |
To determine the physiologic androgen receptor (AR)-dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein E (apoE)-deficient background. |
| T4 |
462-641 |
Sentence |
denotes |
After 8 weeks on a high-fat diet, but not on a normal chow diet, atherosclerosis in aorta was increased in ARKO females (+59% vs. control apoE-deficient mice with intact AR gene). |
| T5 |
642-846 |
Sentence |
denotes |
They also displayed increased body weight (+18%), body fat percentage (+62%), and hepatic triglyceride levels, reduced insulin sensitivity, and a marked atherogenic dyslipidemia (serum cholesterol, +52%). |
| T6 |
847-1080 |
Sentence |
denotes |
Differences in atherosclerosis, body weight, and lipid levels between ARKO and control mice were abolished in mice that were ovariectomized before puberty, consistent with a protective action of ovarian androgens mediated via the AR. |
| T7 |
1081-1404 |
Sentence |
denotes |
Furthermore, the AR agonist dihydrotestosterone reduced atherosclerosis (-41%; thoracic aorta), subcutaneous fat mass (-44%), and cholesterol levels (-35%) in ovariectomized mice, reduced hepatocyte lipid accumulation in hepatoma cells in vitro, and regulated mRNA expression of hepatic genes pivotal for lipid homeostasis. |
| T8 |
1405-1597 |
Sentence |
denotes |
In conclusion, we demonstrate that the AR protects against diet-induced atherosclerosis in female mice and propose that this is mediated by modulation of body composition and lipid metabolism. |
