LitCoin-sentences  

PubMed:25119790 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-176 Sentence denotes Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I.
T2 177-330 Sentence denotes The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated.
T3 331-438 Sentence denotes Tubular proteinuria and oxidative stress were induced by a single injection of maleate (400 mg/kg) in rats.
T4 439-830 Sentence denotes Maleate-induced renal injury included increase in renal vascular resistance and in the urinary excretion of total protein, glucose, sodium, neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl β-D-glucosaminidase (NAG), upregulation of kidney injury molecule (KIM)-1, decrease in renal blood flow and claudin-2 expression besides of necrosis and apoptosis of tubular cells on 24 h.
T5 831-949 Sentence denotes Oxidative stress was determined by measuring the oxidation of lipids and proteins and diminution in renal Nrf2 levels.
T6 950-1085 Sentence denotes Studies were also conducted in renal epithelial LLC-PK1 cells and in mitochondria isolated from kidneys of all the experimental groups.
T7 1086-1187 Sentence denotes Maleate induced cell damage and reactive oxygen species (ROS) production in LLC-PK1 cells in culture.
T8 1188-1359 Sentence denotes In addition, maleate treatment reduced oxygen consumption in ADP-stimulated mitochondria and diminished respiratory control index when using malate/glutamate as substrate.
T9 1360-1428 Sentence denotes The activities of both complex I and aconitase were also diminished.
T10 1429-1492 Sentence denotes All the above-described alterations were prevented by curcumin.
T11 1493-1605 Sentence denotes It is concluded that curcumin is able to attenuate in vivo maleate-induced nephropathy and in vitro cell damage.
T12 1606-1853 Sentence denotes The in vivo protection was associated to the prevention of oxidative stress and preservation of mitochondrial oxygen consumption and activity of respiratory complex I, and the in vitro protection was associated to the prevention of ROS production.