LitCoin-sentences  

PubMed:25006961 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus.
T2 80-182 Sentence denotes Lithium, an effective antipsychotic, induces nephrogenic diabetes insipidus (NDI) in ∼40% of patients.
T3 183-395 Sentence denotes The decreased capacity to concentrate urine is likely due to lithium acutely disrupting the cAMP pathway and chronically reducing urea transporter (UT-A1) and water channel (AQP2) expression in the inner medulla.
T4 396-536 Sentence denotes Targeting an alternative signaling pathway, such as PKC-mediated signaling, may be an effective method of treating lithium-induced polyuria.
T5 537-655 Sentence denotes PKC-alpha null mice (PKCα KO) and strain-matched wild type (WT) controls were treated with lithium for 0, 3 or 5 days.
T6 656-820 Sentence denotes WT mice had increased urine output and lowered urine osmolality after 3 and 5 days of treatment whereas PKCα KO mice had no change in urine output or concentration.
T7 821-976 Sentence denotes Western blot analysis revealed that AQP2 expression in medullary tissues was lowered after 3 and 5 days in WT mice; however, AQP2 was unchanged in PKCα KO.
T8 977-1029 Sentence denotes Similar results were observed with UT-A1 expression.
T9 1030-1081 Sentence denotes Animals were also treated with lithium for 6 weeks.
T10 1082-1205 Sentence denotes Lithium-treated WT mice had 19-fold increased urine output whereas treated PKCα KO animals had a 4-fold increase in output.
T11 1206-1382 Sentence denotes AQP2 and UT-A1 expression was lowered in 6 week lithium-treated WT animals whereas in treated PKCα KO mice, AQP2 was only reduced by 2-fold and UT-A1 expression was unaffected.
T12 1383-1489 Sentence denotes Urinary sodium, potassium and calcium were elevated in lithium-fed WT but not in lithium-fed PKCα KO mice.
T13 1490-1695 Sentence denotes Our data show that ablation of PKCα preserves AQP2 and UT-A1 protein expression and localization in lithium-induced NDI, and prevents the development of the severe polyuria associated with lithium therapy.