LitCoin-sentences  

PubMed:24840785 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats.
T2 117-223 Sentence denotes Aconitine is a major bioactive diterpenoid alkaloid with high content derived from herbal aconitum plants.
T3 224-344 Sentence denotes Emerging evidence indicates that voltage-dependent Na(+) channels have pivotal roles in the cardiotoxicity of aconitine.
T4 345-424 Sentence denotes However, no reports are available on the role of Ca(2+) in aconitine poisoning.
T5 425-544 Sentence denotes In this study, we explored the importance of pathological Ca(2+) signaling in aconitine poisoning in vitro and in vivo.
T6 545-698 Sentence denotes We found that Ca(2+) overload lead to accelerated beating rhythm in adult rat ventricular myocytes and caused arrhythmia in conscious freely moving rats.
T7 699-962 Sentence denotes To investigate effects of aconitine on myocardial injury, we performed cytotoxicity assay in neonatal rat ventricular myocytes (NRVMs), as well as measured lactate dehydrogenase level in the culture medium of NRVMs and activities of serum cardiac enzymes in rats.
T8 963-1072 Sentence denotes The results showed that aconitine resulted in myocardial injury and reduced NRVMs viability dose-dependently.
T9 1073-1290 Sentence denotes To confirm the pro-apoptotic effects, we performed flow cytometric detection, cardiac histology, transmission electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay.
T10 1291-1363 Sentence denotes The results showed that aconitine stimulated apoptosis time-dependently.
T11 1364-1531 Sentence denotes The expression analysis of Ca(2+) handling proteins demonstrated that aconitine promoted Ca(2+) overload through the expression regulation of Ca(2+) handling proteins.
T12 1532-1712 Sentence denotes The expression analysis of apoptosis-related proteins revealed that pro-apoptotic protein expression was upregulated, and anti-apoptotic protein BCL-2 expression was downregulated.
T13 1713-1836 Sentence denotes Furthermore, increased phosphorylation of MAPK family members, especially the P-P38/P38 ratio was found in cardiac tissues.
T14 1837-2045 Sentence denotes Hence, our results suggest that aconitine significantly aggravates Ca(2+) overload and causes arrhythmia and finally promotes apoptotic development via phosphorylation of P38 mitogen-activated protein kinase.