| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-84 |
Sentence |
denotes |
IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages. |
| T2 |
85-194 |
Sentence |
denotes |
Unraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. |
| T3 |
195-334 |
Sentence |
denotes |
IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. |
| T4 |
335-414 |
Sentence |
denotes |
Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. |
| T5 |
415-550 |
Sentence |
denotes |
CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. |
| T6 |
551-716 |
Sentence |
denotes |
Further studies indicated that the CSF-1/CSF-1R axis contributed significantly to IL-3-induced CD11c+ cell generation through enhancing c-Fos-associated monopoiesis. |
| T7 |
717-814 |
Sentence |
denotes |
CD11c+ cells induced by IL-3 or IL-3/CSF-1 were competent in cellular maturation and endocytosis. |
| T8 |
815-929 |
Sentence |
denotes |
Both IL-3 and IL-3/CSF-1 cells lacked classical dendritic cell appearance and resembled macrophages in morphology. |
| T9 |
930-1079 |
Sentence |
denotes |
Both populations produced a high level of IL-10, in addition to IL-1, IL-6 and TNFα, in response to LPS, and were relatively poor T cell stimulators. |
| T10 |
1080-1246 |
Sentence |
denotes |
Collectively, these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages. |
