| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-127 |
Sentence |
denotes |
Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation. |
| T2 |
128-394 |
Sentence |
denotes |
Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. |
| T3 |
395-525 |
Sentence |
denotes |
However, there is no report showing that this technique can be used to predict multichannel blocker potential for QT prolongation. |
| T4 |
526-819 |
Sentence |
denotes |
The aim of this study is to show that FPD from MEA (Multielectrode array) of hiPS-CMs can detect QT prolongation induced by multichannel blockers. hiPS-CMs were seeded onto MEA and FPD was measured for 2min every 10min for 30min after drug exposure for the vehicle and each drug concentration. |
| T5 |
820-972 |
Sentence |
denotes |
IKr and IKs blockers concentration-dependently prolonged corrected FPD (FPDc), whereas Ca(2+) channel blockers concentration-dependently shortened FPDc. |
| T6 |
973-1107 |
Sentence |
denotes |
Also, the multichannel blockers Amiodarone, Paroxetine, Terfenadine and Citalopram prolonged FPDc in a concentration dependent manner. |
| T7 |
1108-1373 |
Sentence |
denotes |
Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD). hiPS-CMs using MEA system and FPDc can predict the effects of drug candidates on QT interval. |
| T8 |
1374-1461 |
Sentence |
denotes |
This study also shows that this assay can help detect EAD for drugs with TdP potential. |
