| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-63 |
Sentence |
denotes |
Effects of ginsenosides on opioid-induced hyperalgesia in mice. |
| T2 |
64-190 |
Sentence |
denotes |
Opioid-induced hyperalgesia (OIH) is characterized by nociceptive sensitization caused by the cessation of chronic opioid use. |
| T3 |
191-291 |
Sentence |
denotes |
OIH can limit the clinical use of opioid analgesics and complicate withdrawal from opioid addiction. |
| T4 |
292-413 |
Sentence |
denotes |
In this study, we investigated the effects of Re, Rg1, and Rb1 ginsenosides, the bioactive components of ginseng, on OIH. |
| T5 |
414-528 |
Sentence |
denotes |
OIH was achieved in mice after subcutaneous administration of morphine for 7 consecutive days three times per day. |
| T6 |
529-643 |
Sentence |
denotes |
During withdrawal (days 8 and 9), these mice were administered Re, Rg1, or Rb1 intragastrically two times per day. |
| T7 |
644-764 |
Sentence |
denotes |
On the test day (day 10), mice were subjected to the thermal sensitivity test and the acetic acid-induced writhing test. |
| T8 |
765-873 |
Sentence |
denotes |
Re (300 mg/kg) inhibited OIH in both the thermal sensitivity test and the acetic acid-induced writhing test. |
| T9 |
874-949 |
Sentence |
denotes |
However, the Rg1 and Rb1 ginsenosides failed to prevent OIH in either test. |
| T10 |
950-1043 |
Sentence |
denotes |
Furthermore, Rg1 showed a tendency to aggravate OIH in the acetic acid-induced writhing test. |
| T11 |
1044-1146 |
Sentence |
denotes |
Our data suggested that the ginsenoside Re, but not Rg1 or Rb1, may contribute toward reversal of OIH. |
