LitCoin-sentences  

PubMed:24477591 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes The -930A>G polymorphism of the CYBA gene is associated with premature coronary artery disease.
T2 96-152 Sentence denotes A case-control study and gene-risk factors interactions.
T3 153-269 Sentence denotes Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis and coronary artery disease (CAD).
T4 270-447 Sentence denotes NADPH oxidases are the main source of ROS in the vasculature. p22phox is a critical component of vascular NADPH oxidases and is encoded by the CYBA (cytochrome b245 alpha) gene.
T5 448-584 Sentence denotes The -930A>G CYBA polymorphism (rs9932581:A>G) modulates the activity of the CYBA promoter, and influences CYBA transcriptional activity.
T6 585-754 Sentence denotes The aim of the present study was to analyze a possible association between the -930A>G polymorphism and CAD and to search for gene-traditional risk factors interactions.
T7 755-781 Sentence denotes 480 subjects were studied:
T8 782-852 Sentence denotes 240 patients with premature CAD, 240 age and sex matched blood donors.
T9 853-965 Sentence denotes The -930A>G polymorphism was genotyped using the TaqMan® Pre-designed SNP Genotyping Assay (Applied Biosystems).
T10 966-1060 Sentence denotes The -930G allele carrier state was a risk factor for CAD (OR 2.03, 95% CI 1.21-3.44, P=0.007).
T11 1061-1167 Sentence denotes A synergistic effect of the -930G allele with overweight/obesity (BMI≥25) and cigarette smoking was found.
T12 1168-1397 Sentence denotes The estimated CAD risk for BMI≥25 and the -930G allele interaction was about 160% greater than that predicted by assuming additivity of the effects, and about 40% greater for interaction of cigarette smoking and the -930G allele.
T13 1398-1528 Sentence denotes Overweight/obesity was a risk factor for CAD only in the -930G allele carriers (P<10(-10)) but not in the AA homozygotes (P=1.00).
T14 1529-1621 Sentence denotes In conclusion the -930A>G CYBA polymorphism is associated with CAD in the Polish population.
T15 1622-1727 Sentence denotes The -930G allele carriers are particularly at risk of consequences of obesity and tobacco smoke exposure.