LitCoin-sentences  

PubMed:24442316 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Cultured mycelium Cordyceps sinensis protects liver sinusoidal endothelial cells in acute liver injured mice.
T2 110-387 Sentence denotes Cultured mycelium Cordyceps sinensis (CMCS) was widely used for a variety of diseases including liver injury, the current study aims to investigate the protective effects of CMCS on liver sinusoidal endothelial cells (LSECs) in acute injury liver and related action mechanisms.
T3 388-488 Sentence denotes The mice were injected intraperitoneally with lipopolysaccharide (LPS) and D-galactosamine (D-GalN).
T4 489-636 Sentence denotes 39 male BABL/c mice were randomly divided into four groups: normal control, model control, CMCS treatment and 1,10-phenanthroline treatment groups.
T5 637-795 Sentence denotes The Serum liver function parameters including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were assayed with the commercial kit.
T6 796-918 Sentence denotes The inflammation and scaffold structure in liver were stained with hematoxylin and eosin and silver staining respectively.
T7 919-1038 Sentence denotes The LSECs and sub-endothelial basement membrane were observed with the scanning and transmission electronic microscope.
T8 1039-1201 Sentence denotes The protein expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in liver were analyzed with Western blotting.
T9 1202-1294 Sentence denotes Expression of von Willebrand factor (vWF) was investigated with immunofluorescence staining.
T10 1295-1657 Sentence denotes The lipid peroxidation indicators including antisuperoxideanion (ASAFR), hydroxyl free radical (·OH), superoxide dismutase (SOD), malondialdehyde and glutathione S-transferase (GST) were determined with kits, and matrix metalloproteinase-2 and 9 (MMP-2/9) activities in liver were analyzed with gelatin zymography and in situ fluorescent zymography respectively.
T11 1658-1738 Sentence denotes The model mice had much higher serum levels of ALT and AST than the normal mice.
T12 1739-2113 Sentence denotes Compared to that in the normal control, more severe liver inflammation and hepatocyte apoptosis, worse hepatic lipid peroxidation demonstrated by the increased ASAFR, ·OH and MDA, but decreased SOD and GST, increased MMP-2/9 activities and VCAM-1, ICAM-1 and vWF expressions, which revealed obvious LSEC injury and scaffold structure broken, were shown in the model control.
T13 2114-2431 Sentence denotes Compared with the model group, CMCS and 1,10-phenanthroline significantly improved serum ALT/AST, attenuated hepatic inflammation and improved peroxidative injury in liver, decreased MMP-2/9 activities in liver tissue, improved integration of scaffold structure, and decreased protein expression of VCAM-1 and ICAM-1.
T14 2432-2568 Sentence denotes CMCS could protect LSECs from injury and maintain the microvasculature integration in acute injured liver of mice induced by LPS/D-GalN.
T15 2569-2700 Sentence denotes Its action mechanism was associated with the down-regulation of MMP-2/9 activities and inhibition of peroxidation in injured liver.