| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-108 |
Sentence |
denotes |
Cholecystokinin-octapeptide restored morphine-induced hippocampal long-term potentiation impairment in rats. |
| T2 |
109-259 |
Sentence |
denotes |
Cholecystokinin-octapeptide (CCK-8), which is a typical brain-gut peptide, exerts a wide range of biological activities on the central nervous system. |
| T3 |
260-451 |
Sentence |
denotes |
We have previously reported that CCK-8 significantly alleviated morphine-induced amnesia and reversed spine density decreases in the CA1 region of the hippocampus in morphine-treated animals. |
| T4 |
452-651 |
Sentence |
denotes |
Here, we investigated the effects of CCK-8 on long-term potentiation (LTP) in the lateral perforant path (LPP)-granule cell synapse of rat dentate gyrus (DG) in acute saline or morphine-treated rats. |
| T5 |
652-752 |
Sentence |
denotes |
Population spikes (PS), which were evoked by stimulation of the LPP, were recorded in the DG region. |
| T6 |
753-930 |
Sentence |
denotes |
Acute morphine (30mg/kg, s.c.) treatment significantly attenuated hippocampal LTP and CCK-8 (1μg, i.c.v.) restored the amplitude of PS that was attenuated by morphine injection. |
| T7 |
931-1073 |
Sentence |
denotes |
Furthermore, microinjection of CCK-8 (0.1 and 1μg, i.c.v.) also significantly augmented hippocampal LTP in saline-treated (1ml/kg, s.c.) rats. |
| T8 |
1074-1240 |
Sentence |
denotes |
Pre-treatment of the CCK2 receptor antagonist L-365,260 (10μg, i.c.v) reversed the effects of CCK-8, but the CCK1 receptor antagonist L-364,718 (10μg, i.c.v) did not. |
| T9 |
1241-1444 |
Sentence |
denotes |
The present results demonstrate that CCK-8 attenuates the effect of morphine on hippocampal LTP through CCK2 receptors and suggest an ameliorative function of CCK-8 on morphine-induced memory impairment. |
