| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-139 |
Sentence |
denotes |
The cytogenetic action of ifosfamide, mesna, and their combination on peripheral rabbit lymphocytes: an in vivo/in vitro cytogenetic study. |
| T2 |
140-233 |
Sentence |
denotes |
Ifosfamide (IFO) is an alkylating nitrogen mustard, administrated as an antineoplasmic agent. |
| T3 |
234-318 |
Sentence |
denotes |
It is characterized by its intense urotoxic action, leading to hemorrhagic cystitis. |
| T4 |
319-478 |
Sentence |
denotes |
This side effect of IFO raises the requirement for the co-administration with sodium 2-sulfanylethanesulfonate (Mesna) aiming to avoid or minimize this effect. |
| T5 |
479-592 |
Sentence |
denotes |
IFO and Mesna were administrated separately on rabbit's lymphocytes in vivo, which were later developed in vitro. |
| T6 |
593-715 |
Sentence |
denotes |
Cytogenetic markers for sister chromatid exchanges (SCEs), proliferation rate index (PRI) and Mitotic Index were recorded. |
| T7 |
716-866 |
Sentence |
denotes |
Mesna's action, in conjunction with IFO reduces the frequency of SCEs, in comparison with the SCEs recordings obtained when IFO is administered alone. |
| T8 |
867-1058 |
Sentence |
denotes |
In addition to this, when high concentrations of Mesna were administered alone significant reductions of the PRI were noted, than with IFO acting at the same concentration on the lymphocytes. |
| T9 |
1059-1224 |
Sentence |
denotes |
Mesna significantly reduces IFO's genotoxicity, while when administered in high concentrations it acts in an inhibitory fashion on the cytostatic action of the drug. |
