LitCoin-sentences  

PubMed:23791840 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy.
T2 136-146 Sentence denotes OBJECTIVE:
T3 147-256 Sentence denotes Both oxidative stress and endoplasmic reticulum stress (ER stress) are causal events in diabetic embryopathy.
T4 257-309 Sentence denotes We tested whether oxidative stress causes ER stress.
T5 310-323 Sentence denotes STUDY DESIGN:
T6 324-883 Sentence denotes Wild-type (WT) and superoxide dismutase 1 (SOD1)-overexpressing day 8.75 embryos from nondiabetic WT control with SOD1 transgenic male and diabetic WT female with SOD1 transgenic male were analyzed for ER stress markers: C/EBP-homologous protein (CHOP), calnexin, eukaryotic initiation factor 2α (eIF2α), protein kinase ribonucleic acid (RNA)-like ER kinase (PERK), binding immunoglobulin protein, protein disulfide isomerase family A member 3, kinases inositol-requiring protein-1α (IRE1α), and the X-box binding protein (XBP1) messenger RNA (mRNA) splicing.
T7 884-892 Sentence denotes RESULTS:
T8 893-1098 Sentence denotes Maternal diabetes significantly increased the levels of CHOP, calnexin, phosphorylated (p)-eIF2α, p-PERK, and p-IRE1α; triggered XBP1 mRNA splicing; and enhanced ER chaperone gene expression in WT embryos.
T9 1099-1168 Sentence denotes SOD1 overexpression blocked these diabetes-induced ER stress markers.
T10 1169-1180 Sentence denotes CONCLUSION:
T11 1181-1284 Sentence denotes Mitigating oxidative stress via SOD1 overexpression blocks maternal diabetes-induced ER stress in vivo.