LitCoin-sentences  

PubMed:22859398 JSONTXT 27 Projects

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Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence.
T2 115-126 Sentence denotes BACKGROUND:
T3 127-383 Sentence denotes To evaluate the association of variation in genes involved in immune response, including IL10, production and detoxification of reactive oxygen species, and repair of oxidative DNA damage with risk of recurrence after surgery for localized prostate cancer.
T4 384-392 Sentence denotes METHODS:
T5 393-489 Sentence denotes We conducted a nested case-control study of men who had a radical prostatectomy in 1993 to 2001.
T6 490-597 Sentence denotes A total of 484 recurrence cases and 484 controls were matched on age, race, and pathologic stage and grade.
T7 598-671 Sentence denotes Germline DNA was extracted from paraffin-embedded unaffected lymph nodes.
T8 672-907 Sentence denotes We genotyped candidate single-nucleotide polymorphisms (SNP) in IL10, CRP, GPX1, GSR, GSTP1, hOGG1, IL1B, IL1RN, IL6, IL8, MPO, NOS2, NOS3, SOD1, SOD2, SOD3, TLR4, and TNF and tagging SNPs in IL10, CRP, GSR, IL1RN, IL6, NOS2, and NOS3.
T9 908-997 Sentence denotes We used conditional logistic regression to estimate OR and 95% confidence intervals (CI).
T10 998-1006 Sentence denotes RESULTS:
T11 1007-1160 Sentence denotes The minor allele (A) in IL10 rs1800872, known to produce less interleukin-10 (IL-10), was associated with a higher risk of recurrence (OR = 1.76, 95% CI:
T12 1161-1307 Sentence denotes 1.00-3.10), and the minor allele (G) in rs1800896, known to produce more IL-10, was associated with a lower risk of recurrence (OR = 0.66, 95% CI:
T13 1308-1319 Sentence denotes 0.48-0.91).
T14 1320-1393 Sentence denotes We also observed associations for candidate SNPs in CRP, GSTP1, and IL1B.
T15 1394-1479 Sentence denotes A common IL10 haplotype and 2 common NOS2 haplotypes were associated with recurrence.
T16 1480-1491 Sentence denotes CONCLUSION:
T17 1492-1630 Sentence denotes Variation in IL10, CRP, GSTP1, IL1B, and NOS2 was associated with prostate cancer recurrence independent of pathologic prognostic factors.
T18 1631-1638 Sentence denotes IMPACT:
T19 1639-1827 Sentence denotes This study supports that genetic variation in immune response and oxidation influence prostate cancer recurrence risk and suggests genetic variation in these pathways may inform prognosis.