LitCoin-sentences  

PubMed:22808010 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation.
T2 150-240 Sentence denotes Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies:
T3 241-482 Sentence denotes Bcl-x levels are elevated in maturing erythroblasts, but not in their progenitors; truncated EPOR alleles that lack a major p85/PI3K recruitment site nonetheless promote polycythemia; and Erk1 disruption unexpectedly bolsters erythropoiesis.
T4 483-662 Sentence denotes To discover novel EPO/EPOR action routes, global transcriptome analyses presently are applied to interrogate EPO/EPOR effects on primary bone marrow-derived CFUe-like progenitors.
T5 663-748 Sentence denotes Overall, 160 EPO/EPOR target transcripts were significantly modulated 2-to 21.8-fold.
T6 749-855 Sentence denotes A unique set of EPO-regulated survival factors included Lyl1, Gas5, Pim3, Pim1, Bim, Trib3 and Serpina 3g.
T7 856-968 Sentence denotes EPO/EPOR-modulated cell cycle mediators included Cdc25a, Btg3, Cyclin-d2, p27-kip1, Cyclin-g2 and CyclinB1-IP-1.
T8 969-1046 Sentence denotes EPO regulation of signal transduction factors was also interestingly complex.
T9 1047-1168 Sentence denotes For example, not only Socs3 plus Socs2 but also Spred2, Spred1 and Eaf1 were EPO-induced as negative-feedback components.
T10 1169-1323 Sentence denotes Socs2, plus five additional targets, further proved to comprise new EPOR/Jak2/Stat5 response genes (which are important for erythropoiesis during anemia).
T11 1324-1409 Sentence denotes Among receptors, an atypical TNF-receptor Tnfr-sf13c was up-modulated >5-fold by EPO.
T12 1410-1542 Sentence denotes Functionally, Tnfr-sf13c ligation proved to both promote proerythroblast survival, and substantially enhance erythroblast formation.
T13 1543-1712 Sentence denotes The EPOR therefore engages a sophisticated set of transcriptome response circuits, with Tnfr-sf13c deployed as one novel positive regulator of proerythroblast formation.