| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-99 |
Sentence |
denotes |
Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis. |
| T2 |
100-111 |
Sentence |
denotes |
BACKGROUND: |
| T3 |
112-309 |
Sentence |
denotes |
The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. |
| T4 |
310-432 |
Sentence |
denotes |
The polymorphism rs2234671 at position Ex2+860G>C of the CXCR1 gene causes a conservative amino acid substitution (S276T). |
| T5 |
433-552 |
Sentence |
denotes |
This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. |
| T6 |
553-703 |
Sentence |
denotes |
Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. |
| T7 |
704-826 |
Sentence |
denotes |
In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. |
| T8 |
827-836 |
Sentence |
denotes |
FINDINGS: |
| T9 |
837-941 |
Sentence |
denotes |
Similar distribution of the allelic and genotypic frequencies were observed between the groups (p>0.05). |
| T10 |
942-954 |
Sentence |
denotes |
CONCLUSIONS: |
| T11 |
955-1104 |
Sentence |
denotes |
The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. |
