LitCoin-sentences  

PubMed:21666969 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Roles of G1359A polymorphism of the cannabinoid receptor gene (CNR1) on weight loss and adipocytokines after a hypocaloric diet.
T2 129-140 Sentence denotes BACKGROUND:
T3 141-359 Sentence denotes A intragenic biallelic polymorphism (1359 G/A) of the CB1 gene resulting in the substitution of the G to A at nucleotide position 1359 in codon 435 (Thr), was reported as a common polymorphism in Caucasian populations.
T4 360-427 Sentence denotes Intervention studies with this polymorphism have not been realized.
T5 428-438 Sentence denotes OBJECTIVE:
T6 439-669 Sentence denotes We decided to investigate the role of the polymorphism (G1359A) of CB1 receptor gene on adipocytokines response and weight loss secondary to a lifestyle modification (Mediterranean hypocaloric diet and exercise) in obese patients.
T7 670-677 Sentence denotes DESIGN:
T8 678-732 Sentence denotes A population of 94 patients with obesity was analyzed.
T9 733-890 Sentence denotes Before and after 3 months on a hypocaloric diet, an anthropometric evaluation, an assessment of nutritional intake and a biochemical analysis were performed.
T10 891-1036 Sentence denotes The statistical analysis was performed for the combined G1359A and A1359A as a group and wild type G1359G as second group, with a dominant model.
T11 1037-1045 Sentence denotes RESULTS:
T12 1046-1231 Sentence denotes Forty seven patients (50%) had the genotype G1359G (wild type group) and 47 (50%) patients G1359A (41 patients, 43.6%) or A1359A (6 patients, 6.4%) (mutant type group) had the genotype.
T13 1232-1357 Sentence denotes In wild and mutant type groups, weight, body mass index, fat mass, waist circumference and systolic blood pressure decreased.
T14 1358-1428 Sentence denotes In mutant type group, resistin (4.15 ± 1.7 ng/ml vs. 3.90 ± 2.1 ng/ml:
T15 1429-1483 Sentence denotes P < 0.05), leptin (78.4 ± 69 ng/ml vs 66.2 ± 32 ng/ml:
T16 1484-1541 Sentence denotes P < 0.05) and IL-6 (1.40 ± 1.9 pg/ml vs 0.81 ± 1.5 pg/ml:
T17 1542-1593 Sentence denotes P < 0.05) levels decreased after dietary treatment.
T18 1594-1605 Sentence denotes CONCLUSION:
T19 1606-1765 Sentence denotes The novel finding of this study is the association of the mutant allele (A1359) with a decrease of resistin, leptin and interleukin-6 secondary to weight loss.