LitCoin-sentences  

PubMed:21325775 JSONTXT 35 Projects

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Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy.
T2 119-347 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level.
T3 348-424 Sentence denotes Several gene mutations of apoE have been reported to be associated with LPG.
T4 425-511 Sentence denotes In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka.
T5 512-593 Sentence denotes The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome.
T6 594-776 Sentence denotes Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries.
T7 777-891 Sentence denotes His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis.
T8 892-960 Sentence denotes It is intriguing that the serum apoE level was within normal limits.
T9 961-1077 Sentence denotes We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products.
T10 1078-1163 Sentence denotes ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4.
T11 1164-1281 Sentence denotes This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE.
T12 1282-1416 Sentence denotes The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous.
T13 1417-1630 Sentence denotes It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries.
T14 1631-1719 Sentence denotes The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated.