| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-102 |
Sentence |
denotes |
Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling. |
| T2 |
103-244 |
Sentence |
denotes |
Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors. |
| T3 |
245-396 |
Sentence |
denotes |
Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to switch to a differentiating cystoblast (CB). |
| T4 |
397-510 |
Sentence |
denotes |
However, downstream effectors of Pum-Nos remain unknown, and how CBs lose their responsiveness to Dpp is unclear. |
| T5 |
511-616 |
Sentence |
denotes |
Here, we identify Brain Tumor (Brat) as a potent differentiation factor and target of Pum-Nos regulation. |
| T6 |
617-763 |
Sentence |
denotes |
Brat is excluded from GSCs by Pum-Nos but functions with Pum in CBs to translationally repress distinct targets, including the Mad and dMyc mRNAs. |
| T7 |
764-920 |
Sentence |
denotes |
Regulation of both targets simultaneously lowers cellular responsiveness to Dpp signaling, forcing the cell to become refractory to the self-renewal signal. |
| T8 |
921-1141 |
Sentence |
denotes |
Mathematical modeling elucidates bistability of cell fate in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat coupling extracellular Dpp regulation to intracellular interpretation. |
