LitCoin-sentences  

PubMed:21163864 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes The M235T polymorphism of the angiotensinogen gene in South Indian patients of hypertrophic cardiomyopathy.
T2 108-121 Sentence denotes INTRODUCTION:
T3 122-253 Sentence denotes Hypertrophic cardiomyopathy (HCM) is a complex disorder and genetically transmitted cardiac disease with a diverse clinical course.
T4 254-448 Sentence denotes The objective of the present study was to examine the association of the T704C polymorphism of exon 2 of the angiotensinogen (AGT) gene with HCM in a South Indian population from Andhra Pradesh.
T5 449-470 Sentence denotes Subjects and methods.
T6 471-746 Sentence denotes One-hundred and fifty HCM (90 sporadic hypertrophic cardiomyopathy [SHCM] and 60 familial hypertrophic cardiomyopathy [FHCM]) patients and 165 age- and sex-matched normal healthy controls without known hypertension and left ventricular hypertrophy were included in the study.
T7 747-980 Sentence denotes DNA was isolated from peripheral leukocytes and the region of interest in the AGT gene bearing a missense mutation methionine to threonine substitution at codon 235 (M235T) of exon 2, was amplified by polymerase chain reaction (PCR).
T8 981-1060 Sentence denotes The PCR products were subjected to restriction digestion with the enzyme SfaNI.
T9 1061-1069 Sentence denotes RESULTS:
T10 1070-1229 Sentence denotes Significant differences were detected in genotypic distribution (p = 0.04) as well as the allelic frequency (p = 0.003) between the SHCM patients and controls.
T11 1230-1286 Sentence denotes The polymorphism did not show any association with FHCM.
T12 1287-1298 Sentence denotes CONCLUSION:
T13 1299-1440 Sentence denotes Our results suggest that the T allele of the AGT gene is significantly associated with SHCM in a South Indian population from Andhra Pradesh.
T14 1441-1521 Sentence denotes However, we did not find significant association of this polymorphism with FHCM.