| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-183 |
Sentence |
denotes |
Impact of CCR5delta32 host genetic background and disease progression on HIV-1 intrahost evolutionary processes: efficient hypothesis testing through hierarchical phylogenetic models. |
| T2 |
184-499 |
Sentence |
denotes |
The interplay between C-C chemokine receptor type 5 (CCR5) host genetic background, disease progression, and intrahost HIV-1 evolutionary dynamics remains unclear because differences in viral evolution between hosts limit the ability to draw conclusions across hosts stratified into clinically relevant populations. |
| T3 |
500-646 |
Sentence |
denotes |
Similar inference problems are proliferating across many measurably evolving pathogens for which intrahost sequence samples are readily available. |
| T4 |
647-909 |
Sentence |
denotes |
To this end, we propose novel hierarchical phylogenetic models (HPMs) that incorporate fixed effects to test for differences in dynamics across host populations in a formal statistical framework employing stochastic search variable selection and model averaging. |
| T5 |
910-1250 |
Sentence |
denotes |
To clarify the role of CCR5 host genetic background and disease progression on viral evolutionary patterns, we obtain gp120 envelope sequences from clonal HIV-1 variants isolated at multiple time points in the course of infection from populations of HIV-1-infected individuals who only harbored CCR5-using HIV-1 variants at all time points. |
| T6 |
1251-1415 |
Sentence |
denotes |
Presence or absence of a CCR5 wt/Δ32 genotype and progressive or long-term nonprogressive course of infection stratify the clinical populations in a two-way design. |
| T7 |
1416-1706 |
Sentence |
denotes |
As compared with the standard approach of analyzing sequences from each patient independently, the HPM provides more efficient estimation of evolutionary parameters such as nucleotide substitution rates and d(N)/d(S) rate ratios, as shown by significant shrinkage of the estimator variance. |
| T8 |
1707-1856 |
Sentence |
denotes |
The fixed effects also correct for nonindependence of data between populations and results in even further shrinkage of individual patient estimates. |
| T9 |
1857-2004 |
Sentence |
denotes |
Model selection suggests an association between nucleotide substitution rate and disease progression, but a role for CCR5 genotype remains elusive. |
| T10 |
2005-2241 |
Sentence |
denotes |
Given the absence of clear d(N)/d(S) differences between patient groups, delayed onset of AIDS symptoms appears to be solely associated with lower viral replication rates rather than with differences in selection on amino acid fixation. |
