LitCoin-sentences  

PubMed:21054465 JSONTXT 43 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography.
T2 112-209 Sentence denotes WHAT IS KNOWN AND OBJECTIVE: CYP2C8 is involved in the cytochrome P450 (CYP) epoxygenase pathway.
T3 210-350 Sentence denotes Arachidonic acid metabolites such as epoxyeicosatrienenoic acids and hydroxyeicosatetrenoic acids, produced may have a role in hypertension.
T4 351-522 Sentence denotes We aimed to develop a medium through-put method for screening samples of known and new mutations of CYP2C8 using denaturing high performance liquid chromatography (DHPLC).
T5 523-652 Sentence denotes METHODS: DNA samples from 200 subjects (hypertensive patients and healthy controls) were screened for SNPs in CYP2C8 using DHPLC.
T6 653-771 Sentence denotes Genotypes and allelic frequencies of CYP2C8 between the healthy controls and patients with hypertension were compared.
T7 772-796 Sentence denotes RESULTS AND DISCUSSIONS:
T8 797-907 Sentence denotes Six variants were detected and two were new; T deletion at 5063 and substitution of C to T at 33468 in exon 8.
T9 908-1004 Sentence denotes Differences in variant frequencies were detected between the controls and hypertensive patients.
T10 1005-1091 Sentence denotes The controls have significantly higher prevalence of C35322C compared to the patients.
T11 1092-1163 Sentence denotes The functional significance of the SNP at 35322 requires further study.
T12 1164-1236 Sentence denotes Having homozygous C35322C could be a protective factor for hypertension.
T13 1237-1264 Sentence denotes WHAT IS NEW AND CONCLUSION:
T14 1265-1384 Sentence denotes Denaturing high performance liquid chromatography is useful for population screening to identify new and existing SNPs.
T15 1385-1486 Sentence denotes A higher frequency of the C35322T SNP was observed among hypertensive patients than control subjects.
T16 1487-1587 Sentence denotes This potentially important observation requires confirmation and the clinical significance assessed.