| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-90 |
Sentence |
denotes |
Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma. |
| T2 |
91-181 |
Sentence |
denotes |
Mantle cell lymphoma (MCL) is a rare and aggressive type of B-cell non-Hodgkin's lymphoma. |
| T3 |
182-281 |
Sentence |
denotes |
Patients become progressively refractory to conventional chemotherapy, and their prognosis is poor. |
| T4 |
282-574 |
Sentence |
denotes |
However, a 38% remission rate has been recently reported in refractory MCL treated with temsirolimus, a mTOR inhibitor.Here we had the opportunity to study a case of refractory MCL who had tumor regression two months after temsirolimus treatment, and a progression-free survival of 10 months. |
| T5 |
575-673 |
Sentence |
denotes |
In this case, lymph node biopsies were performed before and six months after temsirolimus therapy. |
| T6 |
674-861 |
Sentence |
denotes |
Comparison of the two biopsies showed that temsirolimus inhibited tumor cell proliferation through cell cycle arrest, but did not induce any change in the number of apoptotic tumor cells. |
| T7 |
862-1005 |
Sentence |
denotes |
Apart from this cytostatic effect, temsirolimus had an antiangiogenic effect with decrease of tumor microvessel density and of VEGF expression. |
| T8 |
1006-1153 |
Sentence |
denotes |
Moreover, numerous patchy, well-limited fibrotic areas, compatible with post-necrotic tissue repair, were found after 6-month temsirolimus therapy. |
| T9 |
1154-1411 |
Sentence |
denotes |
Thus, temsirolimus reduced tumor burden through associated cytostatic and anti-angiogenic effects.This dual effect of temsirolimus on tumor tissue could contribute to its recently reported efficiency in refractory MCL resistant to conventional chemotherapy. |
