LitCoin-sentences  

PubMed:20709368 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease.
T2 95-216 Sentence denotes Conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in stabilization of the fibrin clot.
T3 217-391 Sentence denotes Fibrinogen consists of three pairs of non-identical polypeptide chains, encoded by different genes (fibrinogen alpha [FGA], fibrinogen beta [FGB] and fibrinogen gamma [FGG]).
T4 392-588 Sentence denotes A functional single nucleotide polymorphism (SNP) in the 3' untranslated region of the FGG gene (FGG 10034C>T, rs2066865) has been associated with deep venous thrombosis and myocardial infarction.
T5 589-696 Sentence denotes Aim of the present study was to analyze the role of this polymorphism in peripheral arterial disease (PAD).
T6 697-810 Sentence denotes The study was designed as case-control study including 891 patients with documented PAD and 777 control subjects.
T7 811-872 Sentence denotes FGG genotypes were determined by exonuclease (TaqMan) assays.
T8 873-956 Sentence denotes FGG genotype frequencies were not significantly different between PAD patients (CC:
T9 957-967 Sentence denotes 57.3%, CT:
T10 968-978 Sentence denotes 36.7%, TT:
T11 979-1010 Sentence denotes 5.8%) and control subjects (CC:
T12 1011-1021 Sentence denotes 60.9%, CT:
T13 1022-1046 Sentence denotes 33.5%, TT 5.6%; p=0.35).
T14 1047-1328 Sentence denotes In a multivariate logistic regression analysis including age, sex, smoking, diabetes, arterial hypertension and hypercholesterolemia, the FGG 10034 T variant was not significantly associated with the presence of PAD (Odds ratio 1.07, 95% confidence interval 0.84 - 1.37; p = 0.60).
T15 1329-1415 Sentence denotes The FGG 10034C>T polymorphism was furthermore not associated with age at onset of PAD.
T16 1416-1533 Sentence denotes We conclude that the thrombophilic FGG 10034 T gene variant does not contribute to the genetic susceptibility to PAD.