LitCoin-sentences  

PubMed:20588063 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-145 Sentence denotes Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.
T2 146-162 Sentence denotes BACKGROUND/AIMS:
T3 163-238 Sentence denotes It is still unclear what happens in the glomerulus when proteinuria starts.
T4 239-525 Sentence denotes Using puromycin aminonucleoside nephrosis (PAN) rats, we studied early ultrastructural and permeability changes in relation to the expression of the podocyte-associated molecules nephrin, α-actinin, dendrin, and plekhh2, the last two of which were only recently discovered in podocytes.
T5 526-534 Sentence denotes METHODS:
T6 535-632 Sentence denotes Using immune stainings, semiquantitative measurement was performed under the electron microscope.
T7 633-704 Sentence denotes Permeability was assessed using isolated kidney perfusion with tracers.
T8 705-752 Sentence denotes Possible effects of ACE inhibition were tested.
T9 753-761 Sentence denotes RESULTS:
T10 762-838 Sentence denotes By day 2, some patchy foot process effacement, but no proteinuria, appeared.
T11 839-907 Sentence denotes The amount of nephrin was reduced in both diseased and normal areas.
T12 908-984 Sentence denotes The other proteins showed few changes, which were limited to diseased areas.
T13 985-1103 Sentence denotes By day 4, foot process effacement was complete and proteinuria appeared in parallel with signs of size barrier damage.
T14 1104-1205 Sentence denotes Nephrin decreased further, while dendrin and plekhh2 also decreased but α-actinin remained unchanged.
T15 1206-1258 Sentence denotes ACE inhibition had no significant protective effect.
T16 1259-1369 Sentence denotes CONCLUSIONS: PAN glomeruli already showed significant pathology by day 4, despite relatively mild proteinuria.
T17 1370-1470 Sentence denotes This was preceded by altered nephrin expression, supporting its pivotal role in podocyte morphology.
T18 1471-1586 Sentence denotes The novel proteins dendrin and plekhh2 were both reduced, suggesting roles in PAN, whereas α-actinin was unchanged.