LitCoin-sentences  

PubMed:20540798 JSONTXT 41 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-91 Sentence denotes Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis.
T2 92-103 Sentence denotes BACKGROUND:
T3 104-190 Sentence denotes The phosphodiesterase 4D (PDE4D) gene was reported as a susceptibility gene to stroke.
T4 191-304 Sentence denotes The genetic effect might be attributed to its role in modulating the atherogenic process in the carotid arteries.
T5 305-476 Sentence denotes Using carotid intima-media thickness (IMT) and plaque index as phenotypes, the present study sought to determine the influence of this gene on subclinical atherosclerosis.
T6 477-485 Sentence denotes METHODS:
T7 486-634 Sentence denotes Carotid ultrasonography was performed on 1013 stroke-free subjects who participated in the health screening programs (age 52.6 +/- 12.2; 47.6% men).
T8 635-772 Sentence denotes Genotype distribution was compared among the high-risk (plaque index > or = 4), low-risk (index = 1-3), and reference (index = 0) groups.
T9 773-898 Sentence denotes We analyzed continuous IMT data and further dichotomized IMT data using mean plus one standard deviation as the cutoff level.
T10 899-1077 Sentence denotes Because the plaque prevalence and IMT values displayed a notable difference between men and women, we carried out sex-specific analyses in addition to analyzing the overall data.
T11 1078-1186 Sentence denotes Rs702553 at the PDE4D gene was selected because it conferred a risk for young stroke in our previous report.
T12 1187-1363 Sentence denotes Previous young stroke data (190 cases and 211 controls) with an additional 532 control subjects without ultrasonic data were shown as a cross-validation for the genetic effect.
T13 1364-1372 Sentence denotes RESULTS:
T14 1373-1490 Sentence denotes In the overall analyses, the rare homozygote of rs702553 led to an OR of 3.1 (p = 0.034) for a plaque index > or = 4.
T15 1491-1589 Sentence denotes When subjects were stratified by sex, the genetic effect was only evident in men but not in women.
T16 1590-1740 Sentence denotes Comparing male subjects with plaque index > or = 4 and those with plaque index = 0, the TT genotype was over-represented (27.6% vs. 13.4%, p = 0.008).
T17 1741-1905 Sentence denotes For dichotomized IMT data in men, the TT genotype had an OR of 2.1 (p = 0.032) for a thicker IMT at the common carotid artery compared with the (AA + AT) genotypes.
T18 1906-1974 Sentence denotes In women, neither IMT nor plaque index was associated with rs702553.
T19 1975-2090 Sentence denotes Similarly, SNP rs702553 was only significant in young stroke men (OR = 1.8, p = 0.025) but not in women (p = 0.27).
T20 2091-2103 Sentence denotes CONCLUSIONS:
T21 2104-2270 Sentence denotes The present study demonstrates a sex-differential effect of PDE4D on IMT, plaque index and stroke, which highlights its influence on various aspects of atherogenesis.