LitCoin-sentences  

PubMed:20534142 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion.
T2 94-105 Sentence denotes BACKGROUND:
T3 106-168 Sentence denotes Prohormone convertase 1 is involved in maturation of peptides.
T4 169-318 Sentence denotes Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations.
T5 319-430 Sentence denotes Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity.
T6 431-560 Sentence denotes We studied whether these SNPs influence the prediabetic traits insulin resistance, beta-cell dysfunction, or glucose intolerance.
T7 561-569 Sentence denotes METHODS:
T8 570-644 Sentence denotes We genotyped 1498 German subjects for SNPs rs6232 and rs6235 within PCSK1.
T9 645-784 Sentence denotes The subjects were metabolically characterized by oral glucose tolerance test with glucose, insulin, proinsulin, and C-peptide measurements.
T10 785-858 Sentence denotes A subgroup of 512 subjects underwent a hyperinsulinemic-euglycemic clamp.
T11 859-867 Sentence denotes RESULTS:
T12 868-943 Sentence denotes The minor allele frequencies were 25.8% for SNP rs6235 and 6.0% for rs6232.
T13 944-1086 Sentence denotes After adjustment for sex and age, we found no association of SNPs rs6235 and rs6232 with BMI or other weight-related traits (all p >or= 0.07).
T14 1087-1345 Sentence denotes Both minor alleles, adjusted for sex, age, BMI and insulin sensitivity were associated with elevated AUCproinsulin and AUCproinsulin/AUCinsulin (rs6235: p(additive) model <or= 0.009, effect sizes 8/8%, rs6232: pdominant model <or= 0.01, effect sizes 10/21%).
T15 1346-1447 Sentence denotes Insulin secretion was not affected by the variants (different secretion parameters, all p >or= 0.08).
T16 1448-1731 Sentence denotes The minor allele of SNP rs6232 was additionally associated with 15% higher OGTT-derived and 19% higher clamp-derived insulin sensitivity (pdom <or= 0.0047), 4.5% lower HOMAIR (pdom = 0.02) and 3.5% lower 120-min glucose (pdom = 0.0003) independently of BMI and proinsulin conversion.
T17 1732-1800 Sentence denotes SNP rs6235 was not associated with parameters of glucose metabolism.
T18 1801-1813 Sentence denotes CONCLUSIONS:
T19 1814-1954 Sentence denotes Like rare mutations in PCSK1, the more common variants tested determine glucose-stimulated proinsulin conversion, but not insulin secretion.
T20 1955-2071 Sentence denotes In addition, rs6232, encoding the amino acid exchange N221D, influences insulin sensitivity and glucose homeostasis.