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PubMed:20523265 JSONTXT 29 Projects

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Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population.
T2 124-132 Sentence denotes PURPOSE:
T3 133-298 Sentence denotes Genes in the complement pathway, including complement factor H (CFH), C2/BF, and C3, have been reported to be associated with age-related macular degeneration (AMD).
T4 299-462 Sentence denotes Genetic variants, single-nucleotide polymorphisms (SNPs), in these genes were geno-typed for a case-control association study in a mainland Han Chinese population.
T5 463-471 Sentence denotes METHODS:
T6 472-637 Sentence denotes One hundred and fifty-eight patients with wet AMD, 80 patients with soft drusen, and 220 matched control subjects were recruited among Han Chinese in mainland China.
T7 638-734 Sentence denotes Seven SNPs in CFH and two SNPs in C2, CFB', and C3 were genotyped using the ABI SNaPshot method.
T8 735-875 Sentence denotes A deletion of 84,682 base pairs covering the CFHR1 and CFHR3 genes was detected by direct polymerase chain reaction and gel electrophoresis.
T9 876-884 Sentence denotes RESULTS:
T10 885-1087 Sentence denotes Four SNPs, including rs3753394 (P = 0.0276), rs800292 (P = 0.0266), rs1061170 (P = 0.00514), and rs1329428 (P = 0.0089), in CFH showed a significant association with wet AMD in the cohort of this study.
T11 1088-1256 Sentence denotes A haplotype containing these four SNPs (CATA) significantly increased protection of wet AMD with a P value of 0.0005 and an odds ratio of 0.29 (95% confidence interval:
T12 1257-1268 Sentence denotes 0.15-0.60).
T13 1269-1410 Sentence denotes Unlike in other populations, rs2274700 and rs1410996 did not show a significant association with AMD in the Chinese population of this study.
T14 1411-1617 Sentence denotes None of the SNPs in CFH showed a significant association with drusen, and none of the SNPs in CFH, C2, CFB, and C3 showed a significant association with either wet AMD or drusen in the cohort of this study.
T15 1618-1739 Sentence denotes The CFHR1 and CFHR3 deletion was not polymorphic in the Chinese population and was not associated with wet AMD or drusen.
T16 1740-1751 Sentence denotes CONCLUSION:
T17 1752-2011 Sentence denotes This study showed that SNPs rs3753394 (P = 0.0276), rs800292 (P = 0.0266), rs1061170 (P = 0.00514), and rs1329428 (P = 0.0089), but not rs7535263, rs1410996, or rs2274700, in CFH were significantly associated with wet AMD in a mainland Han Chinese population.
T18 2012-2355 Sentence denotes This study showed that CFH was more likely to be AMD susceptibility gene at Chr.1q31 based on the finding that the CFHR1 and CFHR3 deletion was not polymorphic in the cohort of this study, and none of the SNPs that were significantly associated with AMD in a white population in C2, CFB, and C3 genes showed a significant association with AMD.