| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-74 |
Sentence |
denotes |
Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. |
| T2 |
75-226 |
Sentence |
denotes |
The nephroprotective effect of coenzyme Q10 was investigated in mice with acute renal injury induced by a single i.p. injection of cisplatin (5 mg/kg). |
| T3 |
227-354 |
Sentence |
denotes |
Coenzyme Q10 treatment (10 mg/kg/day, i.p.) was applied for 6 consecutive days, starting 1 day before cisplatin administration. |
| T4 |
355-472 |
Sentence |
denotes |
Coenzyme Q10 significantly reduced blood urea nitrogen and serum creatinine levels which were increased by cisplatin. |
| T5 |
473-866 |
Sentence |
denotes |
Coenzyme Q10 significantly compensated deficits in the antioxidant defense mechanisms (reduced glutathione level and superoxide dismutase activity), suppressed lipid peroxidation, decreased the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentration, and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administration. |
| T6 |
867-975 |
Sentence |
denotes |
Also, histopathological renal tissue damage mediated by cisplatin was ameliorated by coenzyme Q10 treatment. |
| T7 |
976-1186 |
Sentence |
denotes |
Immunohistochemical analysis revealed that coenzyme Q10 significantly decreased the cisplatin-induced overexpression of inducible nitric oxide synthase, nuclear factor-kappaB, caspase-3 and p53 in renal tissue. |
| T8 |
1187-1356 |
Sentence |
denotes |
It was concluded that coenzyme Q10 represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice. |
