LitCoin-sentences  

PubMed:20428796 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-178 Sentence denotes Effect of the abrogation of TGF-beta1 by antisense oligonucleotides on the expression of TGF-beta-isoforms and their receptors I and II in isolated fibroblasts from keloid scars.
T2 179-290 Sentence denotes Disequilibrium of dermal wound repair can result in continued accumulation of ECM and excessive scar formation.
T3 291-376 Sentence denotes In susceptible genetically predisposed individuals, keloid formation can be observed.
T4 377-469 Sentence denotes Keloid disease represents a benign dermal fibroproliferative tumor that is unique to humans.
T5 470-579 Sentence denotes TGF-beta is known to play a key role in the pathogenesis of this disease which is still not fully understood.
T6 580-696 Sentence denotes The isoforms TGF-beta1 and TGF-beta2 have profibrotic properties, whereas TGF-beta3 may have antifibrotic functions.
T7 697-860 Sentence denotes TGF-beta exerts its influence by binding to type I and type II TGF-beta receptors, thereby forming a complex and activating specific downstream effector molecules.
T8 861-1081 Sentence denotes The aim of this study was to investigate the effect of TGF-beta1 targeting by antisense oligonucleotides on the RNA synthesis and protein expression of TGF-beta isoforms and their receptors in keloid-derived fibroblasts.
T9 1082-1331 Sentence denotes In tissue samples with normal fibroblasts (NFs) serving as control samples, expression of TGF-beta1 and -beta2 was decreased when compared to keloid fibroblasts (KFs), while expression of TGF-beta3 and of TGF-betaRII was significantly higher in NFs.
T10 1332-1439 Sentence denotes In the ELISA assay, abrogation of TGF-beta1 led to a significant decrease in TGF-beta1 and -beta2 (p<0.05).
T11 1440-1481 Sentence denotes Expression of TGF-beta2 mRNA was reduced.
T12 1482-1652 Sentence denotes Expression of TGF-beta3 mRNA revealed contrary patterns in KFs from different patients while expression of TGF-betaRI was found to be equal during the measurement period.
T13 1653-1726 Sentence denotes TGF-betaRII mRNA expression was increased after 48 and 72 h respectively.
T14 1727-1816 Sentence denotes There is growing evidence for a regulatory mechanism between TGF-beta1 and its receptors.
T15 1817-1939 Sentence denotes Our findings support this theory by suggesting interrelations between the different TGF-beta isoforms and their receptors.
T16 1940-2103 Sentence denotes Abnormal response of KFs to TGF-betamight reflect a modification in the regulatory pathway that occurs at the receptor level or during intracellular trans-duction.
T17 2104-2322 Sentence denotes Improving the understanding of TGF-beta in keloid disease could lead to the development of clinically useful therapeutic modalities for treatment of keloid disease or even allow identification of preventive strategies.