LitCoin-sentences  

PubMed:20331935 JSONTXT 43 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-134 Sentence denotes A cross-sectional evaluation of the effect of risperidone and selective serotonin reuptake inhibitors on bone mineral density in boys.
T2 135-145 Sentence denotes OBJECTIVE:
T3 146-316 Sentence denotes The aim of the present study was to investigate the effect of risperidone-induced hyperprolactinemia on trabecular bone mineral density (BMD) in children and adolescents.
T4 317-324 Sentence denotes METHOD:
T5 325-558 Sentence denotes Medically healthy 7- to 17-year-old males chronically treated, in a naturalistic setting, with risperidone were recruited for this cross-sectional study through child psychiatry outpatient clinics between November 2005 and June 2007.
T6 559-625 Sentence denotes Anthropometric measurements and laboratory testing were conducted.
T7 626-754 Sentence denotes The clinical diagnoses were based on chart review, and developmental and treatment history was obtained from the medical record.
T8 755-947 Sentence denotes Volumetric BMD of the ultradistal radius was measured using peripheral quantitative computed tomography, and areal BMD of the lumbar spine was estimated using dual-energy x-ray absorptiometry.
T9 948-956 Sentence denotes RESULTS:
T10 957-1064 Sentence denotes Hyperprolactinemia was present in 49% of 83 boys (n = 41) treated with risperidone for a mean of 2.9 years.
T11 1065-1172 Sentence denotes Serum testosterone concentration increased with pubertal status but was not affected by hyperprolactinemia.
T12 1173-1246 Sentence denotes As expected, bone mineral content and BMD increased with sexual maturity.
T13 1247-1437 Sentence denotes After adjusting for the stage of sexual development and height and BMI z scores, serum prolactin was negatively associated with trabecular volumetric BMD at the ultradistal radius (P < .03).
T14 1438-1665 Sentence denotes Controlling for relevant covariates, we also found treatment with selective serotonin reuptake inhibitors (SSRIs) to be associated with lower trabecular BMD at the radius (P = .03) and BMD z score at the lumbar spine (P < .05).
T15 1666-1764 Sentence denotes These findings became more marked when the analysis was restricted to non-Hispanic white patients.
T16 1765-1900 Sentence denotes Of 13 documented fractures, 3 occurred after risperidone and SSRIs were started, and none occurred in patients with hyperprolactinemia.
T17 1901-1913 Sentence denotes CONCLUSIONS:
T18 1914-2045 Sentence denotes This is the first study to link risperidone-induced hyperprolactinemia and SSRI treatment to lower BMD in children and adolescents.
T19 2046-2202 Sentence denotes Future research should evaluate the longitudinal course of this adverse event to determine its temporal stability and whether a higher fracture rate ensues.