LitCoin-sentences  

PubMed:20105310 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects.
T2 145-156 Sentence denotes BACKGROUND:
T3 157-217 Sentence denotes Prevalence of obesity is increasing to pandemic proportions.
T4 218-312 Sentence denotes However, obese subjects differ in insulin resistance, adipokine production and co-morbidities.
T5 313-471 Sentence denotes Based on fasting plasma analysis, obese subjects were grouped as Low Acylation Stimulating protein (ASP) and Triglyceride (TG) (LAT) vs High ASP and TG (HAT).
T6 472-647 Sentence denotes Subcutaneous (SC) and omental (OM) adipose tissues (n = 21) were analysed by microarray, and biologic pathways in lipid metabolism and inflammation were specifically examined.
T7 648-794 Sentence denotes METHODS: LAT and HAT groups were matched in age, obesity, insulin, and glucose, and had similar expression of insulin-related genes (InsR, IRS-1).
T8 795-923 Sentence denotes ASP related genes tended to be increased in the HAT group and were correlated (factor B, adipsin, complement C3, p < 0.01 each).
T9 924-1036 Sentence denotes Differences between LAT and HAT group were almost exclusively in SC tissue, with little difference in OM tissue.
T10 1037-1162 Sentence denotes Increased C5L2 (p < 0.01), an ASP receptor, in HAT suggests a compensatory ASP pathway, associated with increased TG storage.
T11 1163-1437 Sentence denotes RESULTS: HAT adipose tissue demonstrated increased lipid related genes for storage (CD36, DGAT1, DGAT2, SCD1, FASN, and LPL), lipolysis (HSL, CES1, perilipin), fatty acid binding proteins (FABP1, FABP3) and adipocyte differentiation markers (CEBPalpha, CEBPbeta, PPARgamma).
T12 1438-1516 Sentence denotes By contrast, oxidation related genes were decreased (AMPK, UCP1, CPT1, FABP7).
T13 1517-1691 Sentence denotes HAT subjects had increased anti-inflammatory genes TGFB1, TIMP1, TIMP3, and TIMP4 while proinflammatory PIG7 and MMP2 were also significantly increased; all genes, p < 0.025.
T14 1692-1703 Sentence denotes CONCLUSION:
T15 1704-1924 Sentence denotes Taken together, the profile of C5L2 receptor, ASP gene expression and metabolic factors in adipose tissue from morbidly obese HAT subjects suggests a compensatory response associated with the increased plasma ASP and TG.