LitCoin-sentences  

PubMed:20034406 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus.
T2 120-131 Sentence denotes BACKGROUND:
T3 132-209 Sentence denotes Neuroinflammation occurs after seizures and is implicated in epileptogenesis.
T4 210-375 Sentence denotes CCR2 is a chemokine receptor for CCL2 and their interaction mediates monocyte infiltration in the neuroinflammatory cascade triggered in different brain pathologies.
T5 376-495 Sentence denotes In this work CCR2 and CCL2 expression were examined following status epilepticus (SE) induced by pilocarpine injection.
T6 496-545 Sentence denotes METHODS: SE was induced by pilocarpine injection.
T7 546-608 Sentence denotes Control rats were injected with saline instead of pilocarpine.
T8 609-717 Sentence denotes Five days after SE, CCR2 staining in neurons and glial cells was examined using imunohistochemical analyses.
T9 718-810 Sentence denotes The number of CCR2 positive cells was determined using stereology probes in the hippocampus.
T10 811-878 Sentence denotes CCL2 expression in the hippocampus was examined by molecular assay.
T11 879-887 Sentence denotes RESULTS:
T12 888-944 Sentence denotes Increased CCR2 was observed in the hippocampus after SE.
T13 945-1017 Sentence denotes Seizures also resulted in alterations to the cell types expressing CCR2.
T14 1018-1093 Sentence denotes Increased numbers of neurons that expressed CCR2 was observed following SE.
T15 1094-1174 Sentence denotes Microglial cells were more closely apposed to the CCR2-labeled cells in SE rats.
T16 1175-1317 Sentence denotes In addition, rats that experienced SE exhibited CCR2-labeling in populations of hypertrophied astrocytes, especially in CA1 and dentate gyrus.
T17 1318-1376 Sentence denotes These CCR2+ astroctytes were not observed in control rats.
T18 1377-1468 Sentence denotes Examination of CCL2 expression showed that it was elevated in the hippocampus following SE.
T19 1469-1480 Sentence denotes CONCLUSION:
T20 1481-1579 Sentence denotes The data show that CCR2 and CCL2 are up-regulated in the hippocampus after pilocarpine-induced SE.
T21 1580-1666 Sentence denotes Seizures also result in changes to CCR2 receptor expression in neurons and astrocytes.
T22 1667-1790 Sentence denotes These changes might be involved in detrimental neuroplasticity and neuroinflammatory changes that occur following seizures.