| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-66 |
Sentence |
denotes |
Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients. |
| T2 |
67-78 |
Sentence |
denotes |
BACKGROUND: |
| T3 |
79-172 |
Sentence |
denotes |
Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. |
| T4 |
173-298 |
Sentence |
denotes |
CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. |
| T5 |
299-450 |
Sentence |
denotes |
T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. |
| T6 |
451-590 |
Sentence |
denotes |
Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. |
| T7 |
591-653 |
Sentence |
denotes |
However, information about FOXP3 gene in psoriasis is limited. |
| T8 |
654-664 |
Sentence |
denotes |
OBJECTIVE: |
| T9 |
665-786 |
Sentence |
denotes |
This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population. |
| T10 |
787-795 |
Sentence |
denotes |
METHODS: |
| T11 |
796-939 |
Sentence |
denotes |
In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. |
| T12 |
940-1204 |
Sentence |
denotes |
We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). |
| T13 |
1205-1362 |
Sentence |
denotes |
The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis. |
| T14 |
1363-1371 |
Sentence |
denotes |
RESULTS: |
| T15 |
1372-1609 |
Sentence |
denotes |
We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. |
| T16 |
1610-1750 |
Sentence |
denotes |
We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). |
| T17 |
1751-1890 |
Sentence |
denotes |
However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. |
| T18 |
1891-2004 |
Sentence |
denotes |
There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. |
| T19 |
2005-2225 |
Sentence |
denotes |
In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score >20; adjusted OR=1.97, 95% CI=1.41-2.75). |
| T20 |
2226-2359 |
Sentence |
denotes |
Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36). |
| T21 |
2360-2467 |
Sentence |
denotes |
CONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. |
| T22 |
2468-2520 |
Sentence |
denotes |
Larger studies are needed to confirm these findings. |
