LitCoin-sentences  

PubMed:19549709 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors.
T2 149-160 Sentence denotes BACKGROUND:
T3 161-257 Sentence denotes Treatment options are scarce in pretreated advanced non-small-cell lung cancer (NSCLC) patients.
T4 258-365 Sentence denotes RAD001, an oral inhibitor of the mammalian target of rapamycin (mTOR), has shown phase I efficacy in NSCLC.
T5 366-374 Sentence denotes METHODS:
T6 375-653 Sentence denotes Stage IIIb or IV NSCLC patients, with two or fewer prior chemotherapy regimens, one platinum based (stratum 1) or both chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors (stratum 2), received RAD001 10 mg/day until progression or unacceptable toxicity.
T7 654-704 Sentence denotes Primary objective was overall response rate (ORR).
T8 705-873 Sentence denotes Analyses of markers associated with the mTOR pathway were carried out on archival tumor from a subgroup using immunohistochemistry (IHC) and direct mutation sequencing.
T9 874-882 Sentence denotes RESULTS:
T10 883-953 Sentence denotes Eighty-five patients were enrolled, 42 in stratum 1 and 43 in stratum.
T11 954-1000 Sentence denotes ORR was 4.7% (7.1% stratum 1; 2.3% stratum 2).
T12 1001-1040 Sentence denotes Overall disease control rate was 47.1%.
T13 1041-1130 Sentence denotes Median progression-free survivals (PFSs) were 2.6 (stratum 1) and 2.7 months (stratum 2).
T14 1131-1223 Sentence denotes Common > or =grade 3 events were fatigue, dyspnea, stomatitis, anemia, and thrombocytopenia.
T15 1224-1301 Sentence denotes Pneumonitis, probably or possibly related, mainly grade 1/2, occurred in 25%.
T16 1302-1428 Sentence denotes Cox regression analysis of IHC scores found that only phospho AKT (pAKT) was a significant independent predictor of worse PFS.
T17 1429-1532 Sentence denotes CONCLUSIONS: RAD001 10 mg/day was well tolerated, showing modest clinical activity in pretreated NSCLC.
T18 1533-1607 Sentence denotes Evaluation of RAD001 plus standard therapy for metastatic NSCLC continues.