| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-103 |
Sentence |
denotes |
Growth hormone dose in growth hormone-deficient adults is not associated with IGF-1 gene polymorphisms. |
| T2 |
104-109 |
Sentence |
denotes |
AIMS: |
| T3 |
110-288 |
Sentence |
denotes |
Several SNPs and a microsatellite cytosine-adenine repeat promoter polymorphism of the IGF-1 gene have been reported to be associated with circulating IGF-1 serum concentrations. |
| T4 |
289-491 |
Sentence |
denotes |
Variance in IGF-1 concentrations due to genetic variations may affect different response to growth hormone (GH) treatment, resulting in different individually required GH-doses in GH-deficient patients. |
| T5 |
492-613 |
Sentence |
denotes |
The aim of this study was to test if the IGF-1 gene polymorphisms are associated with the GH-dose of GH-deficient adults. |
| T6 |
614-634 |
Sentence |
denotes |
MATERIALS & METHODS: |
| T7 |
635-1015 |
Sentence |
denotes |
A total of nine tagging SNPs, five additionally selected SNPs and a cytosine-adenine repeat polymorphism were determined in 133 German adult patients (66 men, 67 women; mean age 45.4 years +/- 13.1 standard deviation; majority Caucasian) with GH-deficiency (GHD) of different origin, derived from the prospective Pfizer International Metabolic Study (KIMS) Pharmacogenetics Study. |
| T8 |
1016-1131 |
Sentence |
denotes |
Patients received GH-treatment for 12 months with finished dose-titration of GH and centralized IGF-1 measurements. |
| T9 |
1132-1296 |
Sentence |
denotes |
GH-dose after 1 year of treatment, IGF-1 concentrations, IGF-1-standard deviation score (SDS), the IGF-1:GH ratio and anthropometric data were analyzed by genotype. |
| T10 |
1297-1305 |
Sentence |
denotes |
RESULTS: |
| T11 |
1306-1581 |
Sentence |
denotes |
Except for rs1019731, which showed a significant difference of IGF-1-SDS by genotypes (p = 0.02), all polymorphisms showed no associations with the GH-doses, IGF-1 concentrations, IGF-1-SDS and IGF-1:GH ratio after adjusting for the confounding variables gender, age and BMI. |
| T12 |
1582-1686 |
Sentence |
denotes |
CONCLUSION: IGF-1 gene polymorphisms were not associated with the responsiveness to exogenous GH in GHD. |
| T13 |
1687-1847 |
Sentence |
denotes |
Therefore, genetic variations of the IGF-1 gene seem not to be major influencing factors of the GH-IGF-axis causing variable response to exogenous GH-treatment. |
