LitCoin-sentences  

PubMed:19082493 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-168 Sentence denotes Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients.
T2 169-359 Sentence denotes In the present study we explored the effect of three polymorphisms of the TS gene on overall and progression- free survival of colorectal cancer (CRC) patients subjected to 5FU chemotherapy.
T3 360-507 Sentence denotes A 28 bp variable number of tandem repeats (VNTR), a G/C single nucleotide polymorphism (SNP), and a deletion of 6 bp at position 1494 were studied.
T4 508-619 Sentence denotes The possible combined effect of these DNA polymorphisms on the clinical outcome of patients was also evaluated.
T5 620-732 Sentence denotes A retrospective study was carried out on paraffin-embedded sections from 113 patients diagnosed of advanced CRC.
T6 733-899 Sentence denotes TS genotyping methods were polymerase chain reaction (PCR) for VNTR and PCR, followed by restriction length fragment polymorphism (PCR-RFLP) for SNP and ins/del 6 bp.
T7 900-1109 Sentence denotes To study the combined effect of TS polymorphisms, four categories were defined accordingly to the level of expression attributed to SNP and ins/del 6 bp genotypes: C&allele 6-, C&6+/6+, G&allele6- and G&6+/6+.
T8 1110-1177 Sentence denotes VNTR and ins/del 6 bp genotypes varied with tumour anatomical site:
T9 1178-1347 Sentence denotes 2R/2R genotype was rare in left-sided tumours (7.0% vs. 26.3% of right-sided and 24.1% of rectal cancers; P<0.01), where the variant allele 6- was very frequent (69.0%).
T10 1348-1445 Sentence denotes Instead, most patients with right-sided tumours were wild-type homozygous 6+/6+ (63.9%) (P<0.01).
T11 1446-1566 Sentence denotes Heterozygous 6+/6- genotype was more frequent among tumours classified as C (50.0%) and D (76.5%) Dukes stages (P=0.05).
T12 1567-1659 Sentence denotes None of the studied polymorphisms alone affected overall or progression-free survival (PFS).
T13 1660-1937 Sentence denotes C&6+/6+ and G&6+/6+ combined genotypes were respectively associated to the best and worst PFS (P=0.03 when compared with each other), while combinations carrying the allele 6- determined an intermediate evolution that might be indicative of a variable response to chemotherapy.
T14 1938-2059 Sentence denotes The rate of Dukes B stage tumours was unexpectedly high (59.1%) among patients with the unfavourable G&6+/6+ combination.
T15 2060-2198 Sentence denotes In our study the combination of high TS expression genotypes G&6+/6+ identifies a group of high risk within CRC patients treated with 5FU.