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PubMed:18507837 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-139 Sentence denotes Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.
T2 140-153 Sentence denotes INTRODUCTION:
T3 154-320 Sentence denotes Somatic alterations have been shown to correlate with breast cancer prognosis and survival, but less is known about the effects of common inherited genetic variation.
T4 321-416 Sentence denotes Of particular interest are genes involved in cell cycle pathways, which regulate cell division.
T5 417-425 Sentence denotes METHODS:
T6 426-862 Sentence denotes We examined associations between common germline genetic variation in 13 genes involved in cell cycle control (CCND1, CCND2, CCND3, CCNE1, CDK2 [p33], CDK4, CDK6, CDKN1A [p21, Cip1], CDKN1B [p27, Kip1], CDKN2A [p16], CDKN2B [p15], CDKN2C [p18], and CDKN2D [p19]) and survival among women diagnosed with invasive breast cancer participating in the SEARCH (Studies of Epidemiology and Risk factors in Cancer Heredity) breast cancer study.
T7 863-1010 Sentence denotes DNA from up to 4,470 women was genotyped for 85 polymorphisms that tag the known common polymorphisms (minor allele frequency > 0.05) in the genes.
T8 1011-1118 Sentence denotes The genotypes of each polymorphism were tested for association with survival using Cox regression analysis.
T9 1119-1127 Sentence denotes RESULTS:
T10 1128-1322 Sentence denotes The rare allele of the tagging single nucleotide polymorphism (SNP) rs2479717 is associated with an increased risk of death (hazard ratio = 1.26 per rare allele carried, 95% confidence interval:
T11 1323-1430 Sentence denotes 1.12 to 1.42; P = 0.0001), which was not attenuated after adjusting for tumour stage, grade, and treatment.
T12 1431-1553 Sentence denotes This SNP is part of a large linkage disequilibrium block, which contains CCND3, BYSL, TRFP, USP49, C6ofr49, FRS3, and PGC.
T13 1554-1714 Sentence denotes We evaluated the association of survival and somatic expression of these genes in breast tumours using expression microarray data from seven published datasets.
T14 1715-1847 Sentence denotes Elevated expression of the C6orf49 transcript was associated with breast cancer survival, adding biological interest to the finding.
T15 1848-1859 Sentence denotes CONCLUSION:
T16 1860-1989 Sentence denotes It is possible that CCND3 rs2479717, or another variant it tags, is associated with prognosis after a diagnosis of breast cancer.
T17 1990-2041 Sentence denotes Further study is required to validate this finding.