| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-126 |
Sentence |
denotes |
Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats. |
| T2 |
127-408 |
Sentence |
denotes |
The present study aimed to investigate the anticonvulsant activity as well as the effects on the level of hippocampal amino acid neurotransmitters (glutamate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU) in comparison to its parent compound, valproic acid (VPA). |
| T3 |
409-606 |
Sentence |
denotes |
VPU was more potent than VPA, exhibiting the median effective dose (ED(50)) of 49 mg/kg in protecting rats against pilocarpine-induced seizure whereas the corresponding value for VPA was 322 mg/kg. |
| T4 |
607-842 |
Sentence |
denotes |
In vivo microdialysis demonstrated that an intraperitoneal administration of pilocarpine induced a pronounced increment of hippocampal glutamate and aspartate whereas no significant change was observed on the level of glycine and GABA. |
| T5 |
843-1009 |
Sentence |
denotes |
Pretreatment with either VPU (50 and 100 mg/kg) or VPA (300 and 600 mg/kg) completely abolished pilocarpine-evoked increases in extracellular glutamate and aspartate. |
| T6 |
1010-1179 |
Sentence |
denotes |
In addition, a statistically significant reduction was also observed on the level of GABA and glycine but less than a drastic reduction of glutamate and aspartate level. |
| T7 |
1180-1446 |
Sentence |
denotes |
Based on the finding that VPU and VPA could protect the animals against pilocarpine-induced seizure it is suggested that the reduction of inhibitory amino acid neurotransmitters was comparatively minor and offset by a pronounced reduction of glutamate and aspartate. |
| T8 |
1447-1700 |
Sentence |
denotes |
Therefore, like VPA, the finding that VPU could drastically reduce pilocarpine-induced increases in glutamate and aspartate should account, at least partly, for its anticonvulsant activity observed in pilocarpine-induced seizure in experimental animals. |
| T9 |
1701-1786 |
Sentence |
denotes |
Some other mechanism than those being reported herein should be further investigated. |
