LitCoin-sentences  

PubMed:18439317 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese.
T2 101-112 Sentence denotes BACKGROUND:
T3 113-233 Sentence denotes Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc.
T4 234-418 Sentence denotes A SNP for guanine insertion/deletion (G/D), the -1607 promoter polymorphism, of the MMP1 gene was found significantly affecting promoter activity and corresponding transcription level.
T5 419-475 Sentence denotes Hence it is a good candidate for genetic studies in DDD.
T6 476-484 Sentence denotes METHODS:
T7 485-572 Sentence denotes Southern Chinese volunteers between 18 and 55 years were recruited from the population.
T8 573-652 Sentence denotes DDD in the lumbar spine was defined by MRI using Schneiderman's classification.
T9 653-755 Sentence denotes Genomic DNA was isolated from the leukocytes and genotyping was performed using the Sequenom platform.
T10 756-865 Sentence denotes Association and Hardy-Weinberg equilibrium checking were assessed by Chi-square test and Mann-Whitney U test.
T11 866-874 Sentence denotes RESULTS:
T12 875-1015 Sentence denotes Our results showed substantial evidence of association between -1607 promoter polymorphism of MMP1 and DDD in the Southern Chinese subjects.
T13 1016-1285 Sentence denotes D allelic was significantly associated with DDD (p value = 0.027, odds ratio = 1.41 with 95% CI = 1.04-1.90) while Genotypic association on the presence of D allele was also significantly associated with DDD (p value = 0.046, odds ratio = 1.50 with 95% CI = 1.01-2.24).
T14 1286-1550 Sentence denotes Further age stratification showed significant genotypic as well as allelic association in the group of over 40 years (genotypic: p value = 0.035, odds ratio = 1.617 with 95% CI = 1.033-2.529; allelic: p value = 0.033, odds ratio = 1.445 with 95% CI = 1.029-2.029).
T15 1551-1639 Sentence denotes Disc bulge, annular tears and the Schmorl's nodes were not associated with the D allele.
T16 1640-1651 Sentence denotes CONCLUSION:
T17 1652-1857 Sentence denotes We demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only.
T18 1858-1929 Sentence denotes Further association was identified in individuals over 40 years of age.
T19 1930-2025 Sentence denotes Disc bulge, annular tear as well as Schmorl's nodes were not associated with this polymorphism.