| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-79 |
Sentence |
denotes |
An evaluation of amikacin nephrotoxicity in the hematology/oncology population. |
| T2 |
80-231 |
Sentence |
denotes |
Amikacin is an aminoglycoside commonly used to provide empirical double gram-negative treatment for febrile neutropenia and other suspected infections. |
| T3 |
232-447 |
Sentence |
denotes |
Strategies of extended-interval and conventional dosing have been utilized extensively in the general medical population; however, data are lacking to support a dosing strategy in the hematology/oncology population. |
| T4 |
448-639 |
Sentence |
denotes |
To evaluate amikacin-associated nephrotoxicity in an adult hematology/oncology population, a prospective, randomized, open-label trial was conducted at a university-affiliated medical center. |
| T5 |
640-837 |
Sentence |
denotes |
Forty patients with a diagnosis consistent with a hematologic/oncologic disorder that required treatment with an aminoglycoside were randomized to either conventional or extended-interval amikacin. |
| T6 |
838-1016 |
Sentence |
denotes |
The occurrence of nephrotoxicity by means of an increase in serum creatinine and evaluation of efficacy via amikacin serum concentrations with respective pathogens were assessed. |
| T7 |
1017-1156 |
Sentence |
denotes |
The occurrence of nephrotoxicity was similar between the conventional and extended-interval groups, at 10% and 5%, respectively (P = 1.00). |
| T8 |
1157-1282 |
Sentence |
denotes |
Six patients in the conventional group had a positive culture, compared with none in the extended-interval group (P = 0.002). |
| T9 |
1283-1434 |
Sentence |
denotes |
The occurrence of nephrotoxicity was similar between the two dosing regimens, but the distribution of risk factors was variable between the two groups. |
| T10 |
1435-1466 |
Sentence |
denotes |
Efficacy could not be assessed. |
