LitCoin-sentences  

PubMed:18310445 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in LbetaT2 gonadotrophs.
T2 122-272 Sentence denotes We have shown previously that, in sheep primary pituitary cells, bone morphogenetic proteins (BMP)-4 inhibits FSHbeta mRNA expression and FSH release.
T3 273-433 Sentence denotes In contrast, in mouse LbetaT2 gonadotrophs, others have shown a stimulatory effect of BMPs on basal or activin-stimulated FSHbeta promoter-driven transcription.
T4 434-609 Sentence denotes As a species comparison with our previous results, we used LbetaT2 cells to investigate the effects of BMP-4 on gonadotrophin mRNA and secretion modulated by activin and GnRH.
T5 610-779 Sentence denotes BMP-4 alone had no effect on FSH production, but enhanced the activin+GnRH-induced stimulation of FSHbeta mRNA and FSH secretion, without any effect on follistatin mRNA.
T6 780-957 Sentence denotes BMP-4 reduced LHbeta mRNA up-regulation in response to GnRH (+/-activin) and decreased GnRH receptor expression, which would favour FSH, rather than LH, synthesis and secretion.
T7 958-1104 Sentence denotes In contrast to sheep pituitary gonadotrophs, which express only BMP receptor types IA (BMPRIA) and II (BMPRII), LbetaT2 cells also express BMPRIB.
T8 1105-1262 Sentence denotes Smad1/5 phosphorylation induced by BMP-4, indicating activation of BMP signalling, was the same whether BMP-4 was used alone or combined with activin+/-GnRH.
T9 1263-1493 Sentence denotes We hypothesized that activin and/or GnRH pathways may be modulated by BMP-4, but neither the activin-stimulated phosphorylation of Smad2/3 nor the GnRH-induced ERK1/2 or cAMP response element-binding phosphorylation were modified.
T10 1494-1566 Sentence denotes However, the GnRH-induced activation of p38 MAPK was decreased by BMP-4.
T11 1567-1674 Sentence denotes This was associated with increased FSHbeta mRNA levels and FSH secretion, but decreased LHbeta mRNA levels.
T12 1675-1699 Sentence denotes These results confirm 1.
T13 1700-1931 Sentence denotes BMPs as important modulators of activin and/or GnRH-stimulated gonadotrophin synthesis and release and 2. important species differences in these effects, which could relate to differences in BMP receptor expression in gonadotrophs.