LitCoin-sentences  

PubMed:18189233 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.
T2 83-94 Sentence denotes BACKGROUND:
T3 95-170 Sentence denotes Afro-Caribbeans from Tobago are at high risk of developing prostate cancer.
T4 171-311 Sentence denotes This elevated risk of prostate cancer is shared by populations of African ancestry living in diverse environments in the Western hemisphere.
T5 312-444 Sentence denotes Variation in the ribonuclease L (RNASEL) gene has recently been reported to be associated with an increased risk of prostate cancer.
T6 445-592 Sentence denotes However, whether RNASEL variation contributes to the increased risk of prostate cancer observed in populations of African ancestry remains unclear.
T7 593-601 Sentence denotes METHODS:
T8 602-796 Sentence denotes We resequenced the positional candidate gene RNASEL in 48 prostate cancer cases and genotyped the previously reported R462Q and D541E polymorphisms in 230 prostate cancer cases and 458 controls.
T9 797-897 Sentence denotes We also examined the inhibitor of RNASEL (ABCE1) for variation associated with prostate cancer risk.
T10 898-906 Sentence denotes RESULTS:
T11 907-1035 Sentence denotes We found no evidence of association between R462Q and D541E polymorphisms and prostate cancer risk in our case/control analysis.
T12 1036-1132 Sentence denotes A novel variant (K294E) was identified in a single heterozygous individual with prostate cancer.
T13 1133-1290 Sentence denotes We also observed a 20 bp insertion/deletion polymorphism 1,109 bp upstream of the initiation codon, but this variant was not associated with prostate cancer.
T14 1291-1408 Sentence denotes We identified 16 single nucleotide polymorphisms in the ABCE1 gene, only 3 of which had a minor allele frequency >5%.
T15 1409-1552 Sentence denotes A common A/G transition -1,071 bp from the transcriptional start site was genotyped and showed no evidence of association with prostate cancer.
T16 1553-1565 Sentence denotes CONCLUSIONS:
T17 1566-1778 Sentence denotes Our results suggest that common variation in the putative prostate cancer susceptibility gene, RNASEL, or its inhibitor does not contribute significantly to prostate cancer risk in this Afro-Caribbean population.