LitCoin-sentences  

PubMed:17344330 JSONTXT 43 Projects

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Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen.
T2 115-126 Sentence denotes BACKGROUND:
T3 127-200 Sentence denotes Methadone is prescribed to heroin addicts to decrease illicit opioid use.
T4 201-323 Sentence denotes Prolongation of the QT interval in the ECG of patients with torsade de pointes (TdP) has been reported in methadone users.
T5 324-640 Sentence denotes As heroin addicts sometimes faint while using illicit drugs, doctors might attribute too many episodes of syncope to illicit drug use and thereby underestimate the incidence of TdP in this special population, and the high mortality in this population may, in part, be caused by the proarrhythmic effect of methadone.
T6 641-649 Sentence denotes METHODS:
T7 650-826 Sentence denotes In this cross-sectional study interview, ECGs and blood samples were collected in a population of adult heroin addicts treated with methadone or buprenorphine on a daily basis.
T8 827-943 Sentence denotes Of the patients at the Drug Addiction Service in the municipal of Copenhagen, 450 (approximately 52%) were included.
T9 944-992 Sentence denotes The QT interval was estimated from 12 lead ECGs.
T10 993-1059 Sentence denotes All participants were interviewed about any experience of syncope.
T11 1060-1236 Sentence denotes The association between opioid dose and QT, and methadone dose and reporting of syncope was assessed using multivariate linear regression and logistic regression, respectively.
T12 1237-1245 Sentence denotes RESULTS:
T13 1246-1327 Sentence denotes Methadone dose was associated with longer QT interval of 0.140 ms/mg (p = 0.002).
T14 1328-1383 Sentence denotes No association between buprenorphine and QTc was found.
T15 1384-1476 Sentence denotes Among the subjects treated with methadone, 28% men and 32% women had prolonged QTc interval.
T16 1477-1558 Sentence denotes None of the subjects treated with buprenorphine had QTc interval >0.440 s((1/2)).
T17 1559-1665 Sentence denotes A 50 mg higher methadone dose was associated with a 1.2 (95% CI 1.1 to 1.4) times higher odds for syncope.
T18 1666-1678 Sentence denotes CONCLUSIONS:
T19 1679-1790 Sentence denotes Methadone is associated with QT prolongation and higher reporting of syncope in a population of heroin addicts.