| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-78 |
Sentence |
denotes |
Cytochrome p4501A1 gene variants as susceptibility marker for prostate cancer. |
| T2 |
79-248 |
Sentence |
denotes |
CYP1A1 activates environmental procarcinogens and catalyzes oxidative metabolism of estrogens and is likely to play an important role in the etiology of prostate cancer. |
| T3 |
249-550 |
Sentence |
denotes |
To evaluate this phenomenon, the association between two single nucleotide polymorphisms (A to G transition in exon7 leading to amino acid substitution Ile462Val and T3801C at 3'UTR) of CYP1A1 gene in prostate cancer were analyzed in a case-control study of 100 individuals in South Indian population. |
| T4 |
551-862 |
Sentence |
denotes |
The estimated relative risk was significantly high for individuals with w1/m1 genotype at 3'UTR of CYP1A1 gene (OR-4.64; 95%CI = 1.51-14.86; P < 0.01) whereas the CYP1A1 Ile/Val genotype (w2/m2) on exon 7 was found to be associated with a decreased risk for prostate cancer (OR-0.17; 95%CI = 0.02-0.89; P=0.03). |
| T5 |
863-1110 |
Sentence |
denotes |
A Stratified analysis of the genotypes with age of onset and tumor grade showed the w1/m1 genotype to be significantly associated with an early age of onset; however the tumor grades did not have significant association with the variant genotypes. |
| T6 |
1111-1296 |
Sentence |
denotes |
Thus the present study indicates that individuals with the variant w1/m1 genotype exhibit an increased risk while those with w2/m2 genotype exhibit a decreased risk for prostate cancer. |
