LitCoin-sentences  

PubMed:16810074 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous function.
T2 94-199 Sentence denotes Loss of endothelial cell-derived nitric oxide (NO) in hypertension is a hallmark of arterial dysfunction.
T3 200-340 Sentence denotes Experimental hypertension created by the removal of NO, however, involves mechanisms in addition to decreased arterial vasodilator activity.
T4 341-478 Sentence denotes These include augmented endothelin-1 (ET-1) release, increased sympathetic nervous system activity, and elevated tissue oxidative stress.
T5 479-633 Sentence denotes We hypothesized that increased venous smooth muscle (venomotor) tone plays a role in Nomega-nitro-L-arginine (LNNA) hypertension through these mechanisms.
T6 634-728 Sentence denotes Rats were treated with the NO synthase inhibitor LNNA (0.5 g/L in drinking water) for 2 weeks.
T7 729-843 Sentence denotes Mean arterial pressure of conscious rats was 119 +/- 2 mm Hg in control and 194 +/- 5 mm Hg in LNNA rats (P<0.05).
T8 844-929 Sentence denotes Carotid arteries and vena cava were removed for measurement of isometric contraction.
T9 930-1118 Sentence denotes Maximal contraction to norepinephrine was modestly reduced in arteries from LNNA compared with control rats whereas the maximum contraction to ET-1 was significantly reduced (54% control).
T10 1119-1248 Sentence denotes Maximum contraction of vena cava to norepinephrine (37% control) also was reduced but no change in response to ET-1 was observed.
T11 1249-1387 Sentence denotes Mean circulatory filling pressure, an in vivo measure of venomotor tone, was not elevated in LNNA hypertension at 1 or 2 weeks after LNNA.
T12 1388-1604 Sentence denotes The superoxide scavenger tempol (30, 100, and 300 micromol kg(-1), IV) did not change arterial pressure in control rats but caused a dose-dependent decrease in LNNA rats (-18 +/- 8, -26 +/- 15, and -54 +/- 11 mm Hg).
T13 1605-1779 Sentence denotes Similarly, ganglionic blockade with hexamethonium caused a significantly greater fall in LNNA hypertensive rats (76 +/- 9 mm Hg) compared with control rats (35 +/- 10 mm Hg).
T14 1780-1924 Sentence denotes Carotid arteries, vena cava, and sympathetic ganglia from LNNA rats had higher basal levels of superoxide compared with those from control rats.
T15 1925-2142 Sentence denotes These data suggest that while NO deficiency increases oxidative stress and sympathetic activity in both arterial and venous vessels, the impact on veins does not make a major contribution to this form of hypertension.