LitCoin-sentences  

PubMed:16801510 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.
T2 133-144 Sentence denotes BACKGROUND:
T3 145-210 Sentence denotes Drug-induced long QT syndrome is a serious adverse drug reaction.
T4 211-282 Sentence denotes Methadone prolongs the QT interval in vitro in a dose-dependent manner.
T5 283-476 Sentence denotes In the inpatient setting, the frequency of QT interval prolongation with methadone treatment, its dose dependence, and the importance of cofactors such as drug-drug interactions remain unknown.
T6 477-485 Sentence denotes METHODS:
T7 486-718 Sentence denotes We performed a systematic, retrospective study comparing active or former intravenous drug users receiving methadone and those not receiving methadone among all patients hospitalized over a 5-year period in a tertiary care hospital.
T8 719-886 Sentence denotes A total of 167 patients receiving methadone fulfilled the inclusion criteria and were compared with a control group of 80 injection drug users not receiving methadone.
T9 887-1038 Sentence denotes In addition to methadone dose, 15 demographic, biological, and pharmacological variables were considered as potential risk factors for QT prolongation.
T10 1039-1047 Sentence denotes RESULTS:
T11 1048-1207 Sentence denotes Among 167 methadone maintenance patients, the prevalence of QTc prolongation to 0.50 second((1/2)) or longer was 16.2% compared with 0% in 80 control subjects.
T12 1208-1281 Sentence denotes Six patients (3.6%) in the methadone group presented torsades de pointes.
T13 1282-1412 Sentence denotes QTc length was weakly but significantly associated with methadone daily dose (Spearman rank correlation coefficient, 0.20; P<.01).
T14 1413-1598 Sentence denotes Multivariate regression analysis allowed attribution of 31.8% of QTc variability to methadone dose, cytochrome P-450 3A4 drug-drug interactions, hypokalemia, and altered liver function.
T15 1599-1732 Sentence denotes CONCLUSIONS: QT interval prolongation in methadone maintenance patients hospitalized in a tertiary care center is a frequent finding.
T16 1733-1860 Sentence denotes Methadone dose, presence of cytochrome P-450 3A4 inhibitors, potassium level, and liver function contribute to QT prolongation.
T17 1861-1916 Sentence denotes Long QT syndrome can occur with low doses of methadone.