| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-54 |
Sentence |
denotes |
Genetic alterations in primary glioblastomas in Japan. |
| T2 |
55-223 |
Sentence |
denotes |
Current knowledge of genetic alterations in glioblastomas is based largely on genetic analyses of tumors from mainly caucasian patients in the United States and Europe. |
| T3 |
224-365 |
Sentence |
denotes |
In the present study, screening for several key genetic alterations was performed on 77 primary (de novo) glioblastomas in Japanese patients. |
| T4 |
366-506 |
Sentence |
denotes |
SSCP followed by DNA sequencing revealed TP53 mutations in 16 of 73 (22%) glioblastomas and PTEN mutations in 13 of 63 (21%) cases analyzed. |
| T5 |
507-641 |
Sentence |
denotes |
Polymerase chain reaction (PCR) showed EGFR amplification in 25 of 77 (32%) cases and p16 homozygous deletion in 32 of 77 (42%) cases. |
| T6 |
642-728 |
Sentence |
denotes |
Quantitative microsatellite analysis revealed LOH 10q in 41 of 59 (69%) glioblastomas. |
| T7 |
729-870 |
Sentence |
denotes |
The frequencies of these genetic alterations were similar to those reported for primary glioblastomas at the population level in Switzerland. |
| T8 |
871-1128 |
Sentence |
denotes |
As previously observed for glioblastomas in Europe, there was a positive association between EGFR amplification and p16 deletion (p=0.009), whereas there was an inverse association between TP53 mutations and p16 deletion (p=0.049) in glioblastomas in Japan. |
| T9 |
1129-1260 |
Sentence |
denotes |
Multivariate analyses showed that radiotherapy was significantly predictive for longer survival of glioblastoma patients (p=0.002). |
| T10 |
1261-1455 |
Sentence |
denotes |
SSCP followed by DNA sequencing of the kinase domain (exons 18-21) of the EGFR gene revealed mutations in 2 ou of 69 (3%) glioblastomas in Japan and in 4 of 81 (5%) glioblastomas in Switzerland. |
| T11 |
1456-1797 |
Sentence |
denotes |
The allele frequencies of polymorphisms at codon 787 CAG/CAA (Gln/Gln) in glioblastomas in Japan were G/G (82.4%), G/A (10.8%), A/A (6.8%), corresponding to G 0.878 versus A 0.122, significantly different from those in glioblastomas in Switzerland: G/G (27.2%), G/A (28.4%), A/A (44.4%), corresponding to G 0.414 versus A 0.586 (p < 0.0001). |
| T12 |
1798-2078 |
Sentence |
denotes |
These results suggest that primary glioblastomas in Japan show genetic alterations similar to those in Switzerland, suggesting a similar molecular basis in caucasians and Asians, despite different genetic backgrounds, including different status of a polymorphism in the EGFR gene. |
