LitCoin-sentences  

PubMed:15859361 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and nimesulide associated or not with common non-steroidal anti-inflammatory drugs.
T2 175-186 Sentence denotes BACKGROUND:
T3 187-299 Sentence denotes Acetaminophen (paracetamol--P) and Nimesulide (N) are widely used analgesic-antipyretic/anti-inflammatory drugs.
T4 300-380 Sentence denotes The rate of adverse hypersensitivity reactions to these agents is generally low.
T5 381-484 Sentence denotes On the contrary non-steroidal anti-inflammatory drugs (NSAIDs) are commonly involved in such reactions.
T6 485-569 Sentence denotes Celecoxib (CE) is a novel drug, with high selectivity and affinity for COX-2 enzyme.
T7 570-580 Sentence denotes OBJECTIVE:
T8 581-742 Sentence denotes We evaluated the tolerability of CE in a group of patients with documented history of adverse cutaneous reactions to P and N associated or not to classic NSAIDs.
T9 743-751 Sentence denotes METHODS:
T10 752-862 Sentence denotes We studied 9 patients with hypersensitivity to P and N with or without associated reactions to classic NSAIDs.
T11 863-939 Sentence denotes The diagnosis of P and N-induced skin reactions was based in vivo challenge.
T12 940-1012 Sentence denotes The placebo was blindly administered at the beginning of each challenge.
T13 1013-1097 Sentence denotes After three days, a cumulative dosage of 200 mg of CE in refracted doses were given.
T14 1098-1155 Sentence denotes After 2-3 days, a single dose of 200 mg was administered.
T15 1156-1282 Sentence denotes All patients were observed for 6 hours after each challenge, and controlled again after 24 hours to exclude delayed reactions.
T16 1283-1402 Sentence denotes The challenge was considered positive if one or more of the following appeared: erythema, rush or urticaria-angioedema.
T17 1403-1411 Sentence denotes RESULTS:
T18 1412-1490 Sentence denotes No reaction was observed with placebo and eight patients (88.8%) tolerated CE.
T19 1491-1552 Sentence denotes Only one patient developed a moderate angioedema of the lips.
T20 1553-1564 Sentence denotes CONCLUSION:
T21 1565-1671 Sentence denotes Only one hypersensitivity reaction to CE was documented among 9 P and N-highly NSAIDs intolerant patients.
T22 1672-1782 Sentence denotes Thus, we conclude that CE is a reasonably safe alternative to be used in subjects who do not tolerate P and N.