| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-195 |
Sentence |
denotes |
The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia. |
| T2 |
196-421 |
Sentence |
denotes |
We investigated the relationship between the degeneration of spinal motor neurons and activation of N-methyl-d-aspartate (NMDA) receptors after neuraxial morphine following a noninjurious interval of aortic occlusion in rats. |
| T3 |
422-509 |
Sentence |
denotes |
Spinal cord ischemia was induced by aortic occlusion for 6 min with a balloon catheter. |
| T4 |
510-783 |
Sentence |
denotes |
In a microdialysis study, 10 muL of saline (group C; n = 8) or 30 mug of morphine (group M; n = 8) was injected intrathecally (IT) 0.5 h after reflow, and 30 mug of morphine (group SM; n = 8) or 10 muL of saline (group SC; n = 8) was injected IT 0.5 h after sham operation. |
| T5 |
784-920 |
Sentence |
denotes |
Microdialysis samples were collected preischemia, before IT injection, and at 2, 4, 8, 24, and 48 h of reperfusion (after IT injection). |
| T6 |
921-1071 |
Sentence |
denotes |
Second, we investigated the effect of IT MK-801 (30 mug) on the histopathologic changes in the spinal cord after morphine-induced spastic paraparesis. |
| T7 |
1072-1219 |
Sentence |
denotes |
After IT morphine, the cerebrospinal fluid (CSF) glutamate concentration was increased in group M relative to both baseline and group C (P < 0.05). |
| T8 |
1220-1254 |
Sentence |
denotes |
This increase persisted for 8 hrs. |
| T9 |
1255-1406 |
Sentence |
denotes |
IT MK-801 significantly reduced the number of dark-stained alpha-motoneurons after morphine-induced spastic paraparesis compared with the saline group. |
| T10 |
1407-1564 |
Sentence |
denotes |
These data indicate that IT morphine induces spastic paraparesis with a concomitant increase in CSF glutamate, which is involved in NMDA receptor activation. |
| T11 |
1565-1675 |
Sentence |
denotes |
We suggest that opioids may be neurotoxic in the setting of spinal cord ischemia via NMDA receptor activation. |
